Amino Group Formation/Introduction TRIZ Cases
- Intedanib Synthesis Using Acetic Anhydride and Alkali Bases
Synthesizing intedanib via acetylation with acetic anhydride and alkali hydroxides in aliphatic alcohols.
- Vortioxetine Synthesis Using Cyclic Amide Solvent
A process reacting aniline derivatives with bis(2-alkyl)amine in a cyclic amide solvent to produce vortioxetine.
- Azasteroidal Mimic Synthesis via Isoxazolium Anhydrobase Dimer
A universal synthetic route uses an oxocycloalkenyl isoxazolium anhydrobase intermediate to overcome limited direct methods for creating diverse azasteroids.
- Stereoselective Reductive Amination of 6-Keto Normorphinans
Catalytic transfer hydrogenation converts 6-keto normorphinans into 6-alpha-amino morphinans, achieving high stereoselectivity without hazardous hydrogen gas.
- Ceftolozane Sulfate Synthesis via Molar Ratio Optimization
Adjusting the molar ratio of intermediate compounds to 1.2:1 resolves yield versus waste trade-offs while maintaining pharmaceutical-grade purity standards.
- Asymmetric Synthesis of Azaspiro Compounds via Davis-Ellman Imine
A scalable asymmetric synthesis process for azaspiro compounds using cyclobutane carboxylate addition to a chiral imine.