Bacteria TRIZ Cases

Bacterial cells convert styrene waste into polyhydroxybutyrate using encoded enzymes, eliminating polystyrene transport costs.

Strain CK1 eliminates zearalenone contamination without enterotoxin production or hemolytic activity, preserving feed nutritional quality.

Butyricimonas faecihominis P40-F2a resolves insufficient immune response by increasing pro-inflammatory cytokines and promoting T-cell infiltration into tumors.

Alistipes indistinctus Xia-1 mediates uric acid transport via gut-kidney axis to lower serum levels without drug-induced liver or kidney damage.

A phosphinothricin dehydrogenase mutant enables asymmetric synthesis of L-phosphinothricin with high optical purity.

Nutrient injection stimulates extremophile anaerobic microorganisms to produce metabolites that reduce heavy oil viscosity.

Modified microorganisms increase S-adenosylmethionine cycle enzyme activity to produce vanillin and vanillic acid.

Engineered microbes transform greenhouse gases into beta-ketoadipate, lowering energy consumption compared to petrochemical nylon production.

A Glu247Lys substitution in the transcriptional regulator boosts L-valine production by 22.2% compared to unmodified strains.

Engineered Hydrogenovibrio marinus converts CO2 into therapeutic proteins, eliminating land-intensive afforestation requirements.

A protein complex links two monoclonal antibodies via a cleavable amino acid sequence to form bispecific molecules.

Recombinant methanotrophic bacterium converts methane to succinic acid, eliminating mechanical energy loss and high-pressure capital costs.

Siloxane microcapsules enclose probiotic microbes within a permeable membrane to enable controlled oral delivery, replacing invasive fecal transplants.

Modifying genes like cg1383 and phoU in Corynebacteria resolves the contradiction between high lysine yield and cost-effective manufacturing.

Mixed culture fermentation converts carbon monoxide to higher alcohols, eliminating intermediate separation steps and reducing energy costs.

Introducing specific rpoC mutations enhances RNA polymerase function to increase protein production while avoiding plasmid instability.

Engineered IL-12p40 variants remove protease sites to boost protein stability and production yields.

Expressing ACBP2 in transgenic plants improves survival rates under drought stress by regulating guard cell function.

OmpT1 protease cleaves modified RF1, eliminating premature truncation and boosting full-length protein yield.

Switching to Gram-positive Clostridium species eliminates endotoxin risks while maintaining high productivity on diverse industrial gas streams.

A culture medium using sorbitol or mannitol as the sole sugar source to selectively promote large colony formation by Bifidobacterium breve.

Weissella W3 strain suppresses Streptococcus mutans biofilm formation, resolving insufficient oral disease prophylaxis efficacy of conventional probiotics.

An engineered Escherichia coli strain produces malic acid through integrated metabolic pathways.

Engineering non-magnetic Escherichia coli with heterologous ferritin resolves the contradiction between magnetic manipulation and genetic manipulability.

Genetically engineered Snodgrassella alvi bacteria produce dsRNA within the bee gut to trigger targeted gene silencing.

Inactivating the oxaloacetate decarboxylase gene redirects carbon flux toward L-lysine biosynthesis.

A bioremediation composition uses fatty acid methyl esters to support microbial growth for contaminant degradation.

Amino acid substitutions in amadoriase resist surfactant denaturation, enabling accurate glycated hemoglobin measurement with reduced enzyme concentration.

Chitinase enzymes in a composite preservative break down fungal cell walls, suppressing mold growth and heat damage in baled hay.

High phosphate levels direct Acetobacter metabolism to fix carbon dioxide into light biofuels, resolving productivity and emission trade-offs.

Segmenting the C-terminal tail eliminates variable O-linked glycosylation, resolving aggregation and simplifying analysis.

Novel amino acid dehydrogenase overcomes low activity for bulky side chains like naphthylpyruvic acid, enabling efficient L-amino acid production.

Encapsulating bacteria and viruses in electrospun fibers preserves viability during dry storage, resolving lyophilization losses.

Oral Blautia hydrogenotrophica colonization modulates the gut microbiome to reduce lung tissue inflammation.

Alpha-2,6-sialyltransferase enzymes catalyze sialic acid transfer to lacto-N-neotetraose for targeted oligosaccharide synthesis.

An engineered microorganism variant produces gasoline-range alkanes through introduced enzymatic conversion pathways.