Bacteria TRIZ Cases
- Gut Bacterial Composition for Long-Remission IBD Treatment
A gut bacterial composition using Intestinicoccus colisanans strengthens the gut barrier, lowers inflammation, and helps extend IBD remission.
- Engineered Probiotic Bacteria for PKU Phenylalanine Control
Engineered gut bacteria express phenylalanine-metabolizing enzymes to lower blood phenylalanine in PKU with built-in biosafety controls.
- CD-NTase Nucleotidyltransferases for Diverse Cyclic Messenger Synthesis
Engineered CD-NTases expand cyclic nucleotide synthesis beyond purines, enabling broader study of bacterial immune-modulating second messengers.
- Lactococcus Lactis Temperature-Induced Lysis Without Phage Release
Temperature-triggered Lactococcus lactis lysis releases ripening enzymes for better Cheddar flavor while avoiding phage contamination.
- Engineered Sucrose Phosphorylase for Nucleoside Analogue Synthesis
Engineered sucrose phosphorylase replaces complex chemical synthesis to produce nucleoside analogues for HIV reverse transcriptase inhibitors.
- Attenuated Vibrio Quorum Sensing for Safe Classroom Visualization
Auxotrophic recombinant Vibrio makes quorum sensing visible while improving classroom safety through biological containment.
- Heterologous PrsA Foldase for Non-Native Amylase Secretion
A Bacillus pumilus PrsA foldase in Bacillus licheniformis improves folding and secretion of heterologous amylases for higher enzyme output.
- Chlorotoxin-Secreting Salmonella Vector for Stable Tumor Targeting
An inducible flgM-chlorotoxin vector boosts type III secretion in attenuated Salmonella, improving tumor targeting while preserving stability.
- Live Biotherapeutic Formulation Using Gene-Specific Microbiome Profiling
Gene-specific microbiome profiling guides live biotherapeutic selection to correct vaginal bacterial imbalance and treat bacterial vaginosis.
- Prevotella Merdae Strain for Checkpoint Inhibitor Immune Response
A Prevotella merdae strain boosts T cell proliferation and IFN-γ signaling to improve immune checkpoint inhibitor anticancer efficacy.
- Boolean Genetic Circuits for Tumor-Selective Bacterial Therapeutics
Boolean genetic circuits let engineered bacteria express toxins and immunotherapeutics in tumors while improving specificity and limiting off-target effects.
- Antibacterial Polymer Composition for Non-Eluting Gram-Negative Control
A melt-extrudable antibacterial polymer resists Gram-negative bacteria without elution, avoiding discoloration and toxicity issues of existing agents.
- Engineered TrpB Subunits for Independent Non-Canonical Amino Acid Synthesis
Specific TrpB mutations restore standalone catalytic activity and stability, enabling higher-yield non-canonical amino acid production.
- Anaerobic Fermentation Stirring Profiles for Higher Gas Output
Stage-based stirring raises hydrolysis early, then protects microbes during peak fermentation to shorten cycles and cut energy use.
- Non-Mucin-Degrading Bacterial Composition for Inflammatory Disease
Modified non-mucin-degrading bacteria reduce gut inflammation by outcompeting wild-type strains while preserving intestinal mucus integrity.
- Gut Microbiome Modulation for Immune Checkpoint Response
Specific butyrate-producing bacteria improve immune checkpoint blockade response by reshaping gut microbes and immune cell balance in cancer.
- Attenuated Salmonella VC1 Secretion Vector for Safer Cancer Therapy
An flgM-VC1-flhDC vector boosts type III secretion and immune stimulation in attenuated Salmonella while improving stability for cancer treatment.