Carboxylic Acid Amide Separation/Purification TRIZ Cases

A carbonyl-ligand metal chelate suppresses self-polymerization and coloration in amido monomers during high-temperature storage.

Cooling precipitation followed by MEK–C6–C7 hydrocarbon crystallization purifies N-vinyl monomer for improved polymerizability and productivity.

This case combines basic pH adjustment, chloroform extraction, and distillation to recover reusable DMF from salt-laden aqueous streams.

A method for producing highly polymerizable N-vinyl carboxylic acid amide monomers using a mixed solvent of toluene and aliphatic hydrocarbons.

Distilling methanol under reduced pressure adjusts solvent composition to increase crystallization yield and reduce mother liquor volume.

Replacing expensive preparative liquid chromatography, ethanol crystallization achieves USP-grade purity while reducing solvent consumption and processing time.

Heating crude PEA with a base catalyst converts ester contaminants into soluble salts, enabling high-purity isolation without sacrificing yield.

Replacing chromatography with optimized crystallization in 1-methoxy-2-propanol reduces energy consumption and processing time.

A purification method for N-vinyl carboxylic acid amide monomers using sequential cooling and solvent crystallization steps.

Potassium salt inhibitors prevent self-polymerization in N-vinyl pyrrolidone monomers, extending shelf life without color deepening or toxicity.

Controlled acetaldehyde addition stabilizes aqueous acrylamide by suppressing polymerization without degrading quality or corroding iron surfaces.

Dissolving acylamino acids in high-boiling extraction solvents creates stable stock solutions for industrial processing.

A 2-hydroxyarylamide derivative inhibits TMPRSS4 serine protease activity to suppress cancer cell infiltration.

Converting ABA monomethylester to monoacid via hydrolysis removes dimer impurities and simplifies purification steps.

Crystallizing iodixanol with controlled solvent addition reduces energy consumption and eliminates expensive chromatography steps.

Hydrating acrylonitrile with a nitrile hydratase catalyst yields 40-60% acrylamide, eliminating energy-intensive distillation steps.

Segmented distillation with condensate recycling reduces thermal decomposition losses while maintaining high recovery rates of N-(α-alkoxyethyl)formamide.

Racemizing chiral resolving mother liquor with aromatic hydrocarbons recovers 3-carbamoymethyl-5-methylhexanoic acid.