Compound Screening TRIZ Cases
- Irreversible Btk Inhibitors via Michael Acceptor Covalent Bonding
Irreversible kinase inhibitors target Bruton's tyrosine kinase using a Michael acceptor moiety to form covalent bonds with cysteine residues.
- Isopeptidase Activity Probe for High Throughput Screening
Fluorescent isopeptidase probes detect enzyme activity in biological samples, resolving low throughput and high labor intensity constraints.