Compound Screening TRIZ Cases
- Odorant Receptor Identification via Single-Cell Sequencing
Single-cell sequencing identifies activated odorant receptors directly from native olfactory neurons.
- Alpha-Synuclein Toxicity Modulators via Gene Expression Control
Compounds modulate specific gene expression to inhibit alpha-synuclein mediated cellular toxicity in neuronal cells.
- Peptide Inhibitors for Galectin-7 Dimerization
Peptides targeting specific galectin-7 residues block dimer formation, resolving the trade-off between inhibitor efficacy and molecular weight.
- Atlastin 2 Inhibitor Mitigates Alzheimer's Mitochondrial Dysfunction
An Atlastin 2 inhibitor composition reduces endoplasmic reticulum and mitochondria binding to address cellular dysfunction.
- Activin-ActRII Antagonists for Refractory Anemia
Soluble ActRII polypeptides bypass erythropoietin resistance to raise red blood cell levels without compromising bone density.
- Exosome GCC2 Marker for Non-Invasive Lung Cancer Diagnosis
GCC2-exosome marker composition detects lung cancer via specific primer or antibody binding.
- Androgen Receptor Condensate Modulators for Prostate Cancer Resistance
AR condensate modulators target the intrinsic disorder domain to decrease transcriptional complex levels.
- PMVK siRNA Inhibitors Enhance Radiation Sensitivity in Cancer Cells
PMVK inhibiting siRNA reduces protein levels to enhance radiation sensitivity, overcoming resistance without damaging normal tissues.
- Sol-Gel Protein Chip for High-Throughput PPI Screening
A sol-gel protein chip immobilizes target proteins to enable rapid screening of inhibitors against specific molecular interactions.
- Multi-omics Platform for Rapid Drug Mechanism Identification
Multi-omics platform identifies drug mechanisms of action through integrated transcriptomics, proteomics, and metabolomics analysis.
- Antibody Selection Using Triple Knockout Pro-B Cells
Triple knockout pro-B cells express autonomously active B-cell receptors to select antibodies that bind tumor epitopes while sparing healthy cells.
- T1R Taste Receptor Assay Counter-Screening for False Positives
Segmented heteromeric and homomeric T1R receptor assays distinguish physiologically relevant interactions to improve prediction accuracy.
- Capacitive Biosensor Using Aptamers for Rapid Microorganism Identification
Aptamer-functionalized capacitive biosensors detect microorganisms via real-time capacitance changes.
- MYCBP2 Ligase Screening Assay Using Hydroxy Substrates
A screening assay identifies MYCBP2 modulators using hydroxy-containing substrates to measure ligase activity.