Compound Screening TRIZ Cases
- Additive Selection for Nitrosation Suppression in Pharmaceutical Formulations
This case screens additives with amine and NOx sources to suppress nitrosation while preserving pharmaceutical composition quality.
- Photocrosslinking Antigen Screening for Diverse Epitope-Specific Antibodies
UV-activated antigen crosslinking selectively enriches epitope-specific antibodies, preserving sequence diversity during screening.
- Cathepsin L Fluorogenic Probe for Selective Low-Background Detection
CTLAP uses optimized peptide positions to detect cathepsin L rapidly while limiting signals from cathepsins B and C.
- CRY1 Secondary-Pocket Agents for Precise Circadian Resetting
Target CRY1’s secondary pocket to disrupt CLOCK-BMAL1 and reset rhythms precisely.
- SP-D Oligomer Characterization Using AF4-MALLS for Active Dodecamers
This case uses AF4-MALLS to quantify SP-D oligomers and support functional dodecamer production in surfactant formulations.
- Brain-Penetrant Allosteric α1A-AR Activators for Cognitive Function
Brain-penetrant α1A-AR activators support cognition while limiting blood pressure effects.
- PMP Inhibitor Screening With Patient-Derived Stable Cell Lines
This case combines patient-derived stable PMP cell lines, high-throughput screening, and metabolomics to identify targeted inhibitors.
- Trained Classifier Imaging for Healthy and Diseased Myotube Detection
Single-myotube image analysis improves disease-state differentiation for compound potency assessment and patient selection.
- Tumor Molecular Profiling for Refractory Cancer Treatment Selection
IHC, microarray, FISH, and DNA sequencing compare tumor profiles with rules to identify overlooked treatment options.