Compounds Screening/Testing TRIZ Cases

Selective monoclonal antibodies bind pathological tau over native tau to detect aggregates and limit tau spread in tauopathy models.

A four-mutation Drosophila pancreatic cancer model enables efficient screening of kinase inhibitor combinations with improved treatment relevance.

A nasal ACTH formulation with chitosan enables saliva cortisol testing for adrenal insufficiency without blood sampling or cannulation.

A PVDF capsule tumor-immune model speeds in vivo immunoregulatory drug screening while enabling biomarker detection and efficacy analysis.

Saliva biomarker sensing tracks tooth movement and appliance wear, enabling treatment adjustments when orthodontic forces or compliance fall short.

CML-induced zebrafish embryos and adults enable lower-cost screening of anti-inflammatory agents for cytokine storm, survival, and neuroparalysis.

Recombinant invasive tumor cells and luciferase imaging shorten orthotopic metastasis studies while improving live tracking and data robustness.

Layered allergen cavities and app-guided image analysis improve self-administered skin testing sensitivity, reliability, and access.

Barcode cells with unique SNP profiles let many biomaterial capsules be tested at one implant site, cutting animal use and screening cost.

Multiple human cytokine transgenes improve hematopoietic and tumor xenograft engraftment for in vivo immune-cancer studies.

Combining APOE4, TREM2 R47H, and mutant APP in one mouse improves late-onset Alzheimer’s modeling for compound screening.

Transgenic human cytokines enable conditioning-free engraftment of T, NK, and myeloid cells while reducing GvHD and model cost.

Reporter islets implanted in the eye enable non-invasive tracking of individual islet remodeling over time to reflect pancreatic status.

A chimeric human-mouse IL-15 gene helps mice support human immune cell development and improves IL-15 drug screening relevance.

Non-invasive KiMBI reporters use bioluminescent complementation to track kinase inhibition in vivo, avoiding costly tissue sampling.

Human IL-6 knock-in rodents mimic the bone marrow niche to support myeloma and hematopoietic cell engraftment with lower xenorejection.

Conditional human CASP4 expression in mouse neurons reproduces TDP-43 nuclear loss and cytoplasmic aggregation while avoiding widespread apoptosis.

AI models infer absolute metabolic flux from single-time-point tracer metabolite data, reducing long in-vivo experiments while preserving flux accuracy.

Patient-specific ecDNA oncogene profiling guides targeted glioblastoma drug selection and PDX validation to inhibit tumor growth.

A mouse-human chimeric c-KIT preserves mouse SCF binding and signaling while enabling evaluation of anti-human c-KIT inhibitors.

Anti-PSGL-1 antibodies shift tumor-associated myeloid cells toward pro-inflammatory macrophages, improving CD8+ T cell killing and checkpoint response.

By combining Thy1-SNCA with Clu knockout, this mouse model brings PD-like motor and pathology features forward to shorten studies.

Engineered mice expressing hSCF, hGM-CSF, hIL-3, and hCSF1 support human stem cell and tumor engraftment for in vivo immunotherapy testing.

Skin-specific recombinase and shRNA silencing of Ptch1 and p53 enable rapid BCC induction without lethal systemic effects.