Compounds Screening/Testing TRIZ Cases
- Riluzole Mitigates Antineoplastic Neurotoxicity
Riluzole corrects oxaliplatin-induced cold hypersensitivity, mitigating sensory symptoms while maintaining cancer treatment efficacy.
- Metabolic Isotope Labeling via Intermediary Organisms
Intermediary organisms transfer stable isotopes to target fish, resolving synthetic media complexity while achieving high enrichment.
- Ube3a-Deficient Rat Model for Angelman Syndrome Research
A UBE3A-deficient rat model created via CRISPR technology enables comprehensive pre-clinical testing of potential therapeutic agents.
- Soluble Toso Protein and Checkpoint Inhibitors for Cancer Immune Modulation
Combination therapy with soluble Toso protein and checkpoint inhibitors increases lymphocyte infiltration in tumors.
- Dicarba-closo-dodecaborane Compounds for Selective ERβ Agonism
Selective dicarba-closo-dodecaborane agonists activate ERβ to treat cancer and inflammatory diseases while avoiding ERα-related adverse effects.
- Radiomics Classifier for NSCLM Immunotherapy Response Prediction
A machine learning classifier analyzes serial CT radiomic features to predict immunotherapy response in non-small cell lung cancer patients.
- GPR45 Gene Knockout Mouse Model for Obesity Research
A GPR45 gene knockout mouse model mimics human obesity pathogenesis for drug screening.
- Hybrid MRI-PET Scanner Simultaneous Neurodegenerative Vascular Detection
A hybrid MRI-PET scanner acquires simultaneous positron emission and magnetic resonance data for precise brain imaging.
- Transgenic Mouse Senescent Cell Clearance via p16INK4a Promoter
A transgenic mouse model uses a p16INK4a promoter to drive selective apoptosis in aging cells.
- Anthocyanin-impregnated wound dressings for pH monitoring
Anthocyanin dyes in wound dressings change color with pH levels, detecting infection and healing progress without complex electronics.
- Engineered Rodent Model for Human Lipid Metabolism
Engineered rodents expressing human Angptl8 provide an in vivo model for assessing therapeutic efficacy against hypertriglyceridemia.
- Enolase 1 Muscle Delivery for Glucose Normalization
Enolase 1 treatment normalizes blood glucose by enhancing glucose uptake in muscle, reversing vascular damage without debilitating side effects.
- IL-33 Transgenic Mouse Model for Atopic Dermatitis Research
Keratin promoter-driven IL-33 expression creates a transgenic mouse model that reproduces human atopic dermatitis symptoms for accurate drug evaluation.
- NaPi2b Antibody Detection for Cancer Therapy Stratification
Anti-NaPi2b antibodies detect tumor expression levels to enable targeted therapy selection.
- Bilirubin Detection via Gold Nanocluster Luminescence Quenching
Gold nanocluster luminescence quenched by copper ions recovers upon bilirubin binding, resolving low sensitivity in non-invasive thumb impression diagnostics.
- Humanized C5 and C3 Rodent Models for Complement System Evaluation
Replacing rodent C5 and C3 genes with human sequences enables accurate pharmacokinetic evaluation of therapeutic molecules.