Depsipeptides TRIZ Cases
- Polymer-Silica Hybrid Pdots for Bright Stable Fluorescent Probes
An interpenetrating polymer-silica network improves fluorescence brightness, photostability, and colloidal stability for biological probes.
- HlyA Fusion Variants for Soluble and Stable Protein Secretion
Engineered HlyA fusion variants improve recombinant protein solubility, proteolytic stability, secretion yield, and renaturation efficiency.
- Novel alkylhydroperoxidase ahpd family core domain variant, and method for producing l-glutamic acid by using same
Targeted AhpD core-domain mutation improves peroxide response in recombinant strains, raising L-glutamic acid fermentation yield.
- Extracellular Brazzein Secretion for Higher Yield Purification
Directing Brazzein secretion into the culture medium raises yield and simplifies purification by avoiding periplasmic extraction steps.
- Methanol-Free Yeast Promoters for Recombinant Protein Expression
Novel yeast promoters replace methanol induction to cut cost, shorten fermentation, and avoid peroxide-related protein degradation.
- Engineered Glyphosate Biosensor Using EcPhnD Pocket Mutations
EcPhnD binding-pocket mutations enable reagentless fluorescent glyphosate detection with high sensitivity and reusable sensing.
- Integrated Display-Expression Vectors for High-Throughput Binder Screening
Engineered restriction sites and ligation steps convert display vectors into expression vectors with over 90% efficiency, speeding binder characterization.
- Single-Chain Photoswitch Protein for Light-Controlled Split Protein Binding
A fused scMagnet links pMag and nMag in one polypeptide to boost light-controlled split protein binding with minimal leak activity.
- IL-2 Variants With Selective Receptor Binding for Treg Control
Amino acid substitutions in IL-2 shift receptor binding to stimulate or inhibit Tregs while reducing toxicity and dosing burden.
- Thaumatin-Brazzein Sweetener Blend for Off-Taste Reduction
A purified thaumatin II and brazzein ratio improves sweetness synergy, cuts bitter off-notes, and delivers a better temporal profile.
- Gamma-Glu-Val-Gly Fermentation via tdh/kbl-Engineered Enterobacteriaceae
Engineered Enterobacteriaceae overexpress tdh and kbl to ferment and accumulate γ-Glu-Val-Gly more efficiently than complex synthesis routes.
- Engineered PapG mRNA-LNP Antigens With Reduced Ligand Binding
Engineered PapG mRNA-LNP antigens lower ligand binding while preserving immunogenicity, enabling scalable E. coli vaccine development.
- HLA-DQ8 D-Peptides for Blocking Islet Antigen Presentation
D-amino acid peptides bind HLA-DQ8 to block InsB:9-23 presentation, limiting T-cell attack on beta cells without systemic immunosuppression.