Depsipeptides TRIZ Cases
- Mutant IscR Apoprotein Cell Factories for Enhanced Biochemical Yields
Deleting the iscR gene prevents toxic holo-protein formation, allowing high-level Fe-S cluster polypeptide expression without growth inhibition.
- Amphipathic Peptides for Viral Vector Production
Amphipathic peptides reduce cytotoxicity and improve full-to-empty particle ratios during viral vector manufacturing.
- Synthetic Gene Optimization via Sequence Context Modeling
A method optimizes candidate gene sequences by modeling target system genomes to enhance expression levels.
- Multi-antigenic Malaria Vaccine via Lentiviral Screening
Lentiviral screening isolates conserved Plasmodium polypeptides to overcome partial protection limits of existing malaria vaccines.
- HLA-G Antigenic Fragment Broad Spectrum Vaccine
Antigenic fragments derived from HLA-G induce high-titer antibodies to combat tumors and viruses.
- Activated Carbon Adsorption for Glycoalkaloid Removal
Activated carbon adsorbs glycoalkaloids from aqueous potato protein solutions, achieving residual levels below 10 ppm without significant protein loss.
- Pseudozyma tsukubaensis Itaconic Acid Production
Recombinant Pseudozyma tsukubaensis produces itaconic acid while suppressing malate by-product formation.
- Mechanosensitive Channels for Intraocular Pressure Control
MscL channels regulate intraocular pressure by sensing membrane tension and opening pores to release cytoplasmic fluid.
- Soybean Variety 5PLAY23 Breeding Stability and Yield
Soybean variety 5PLAY23 accelerates breeding cycles by combining disease resistance with yield stability across environments.
- Pichia pastoris Surface Display System for Homogeneous Glycans
Mutant OCH1 alleles in Pichia pastoris yield homogeneous N-glycans, resolving antigenicity issues from high mannose oligosaccharides.
- Glycol Ether Phase Separation for Protein Concentration
A method using glycol ethers with inverse solubility to extract water from aqueous protein solutions.
- Silstatin Compounds Derivatizable Groups Antibody Conjugation
Silstatin compounds replace native amino acids with derivatizable analogs to enable antibody conjugation without losing anticancer activity.
- EPCR Selection for Hematopoietic Stem Cell Expansion
Switching to stable EPCR markers resolves culture instability, enabling reliable HSC purification and functional analysis.
- Purified FabI Polypeptides for Antimicrobial Target Discovery
Purified FabI polypeptides from Francisella tularensis enable high-throughput structural characterization of novel antimicrobial targets.
- Auto-developing Protein Marker Kit for Western Blotting
Regularly-weighted recombinant proteins auto-develop on film to eliminate manual copying and staining heterogeneity in Western blotting.