Depsipeptides TRIZ Cases
- Stabilized Peptide-MHC Complex via Disulphide Bond Linkage
A disulphide bond links the peptide C-terminal anchor to the MHC F pocket, creating a stabilized complex.
- Genetically Modified Animal MHC Expression for Xenotransplantation
Genetically modified animals express specific MHC molecules to reduce immune rejection and address organ shortage.
- Genetically Encoded Biosensor Conformational Signal Transduction
Modular recombinant peptides expand detectable analyte ranges while resolving signal distinction from noise through allosteric framework regulation.
- Modified FcγRIIIb Polypeptides for TRALI Risk Detection
Engineered Fc gamma receptor type IIIb polypeptides enable sensitive detection of human neutrophil antigen antibodies.
- Anti-NKp30 Single Domain Antibody for Immune Activation
Anti-NKp30 single domain antibodies activate NK cells and gamma-delta T cells, bypassing CD16 polymorphism limitations.
- Silk Fibroin Extraction Using Basic Ionic Liquids
Basic ionic liquids extract Bombyx mori silk fibroin powder while preventing protein degradation from toxic solvents.
- FimH-CsgA-PapG Fusion Proteins for UPEC Vaccine
FimH-CsgA-PapG fusion proteins overcome limited protection from single-adhesin vaccines by simultaneously blocking multiple bacterial adherence pathways.
- Darbepoetin Purification via Cation Exchange Chromatography
Flow-through cation exchange chromatography separates low pI isoforms and inactivates viruses, reducing process complexity.
- Recombinant E. coli for High-Yield Alanine Fermentation
Engineers modify metabolic flux via gcvTHP overexpression and gene deletions to resolve low yield contradictions in industrial fermentation.
- Iron Exporter Overexpression in Enterobacteriaceae for L-Amino Acid Fermentation
Overexpressing iron exporter genes in Enterobacteriaceae bacteria to increase L-amino acid productivity.