Digestive System TRIZ Cases
- Anti-HER3 Antibody Combination Therapy for HER2-Normal Cancers
Combining anti-HER3 antibodies with HER2 or HER1 binders creates a unified therapeutic regimen.
- Inducing Tumor Hypoxia for Selective Bioreductive Agent Activation
Vascular disrupting agents create localized tumor hypoxia to selectively activate bioreductive prodrugs, reducing systemic toxicity from normal tissue exposure.
- Tetraether Lipid Liposomes for Oral Hepatic Drug Delivery
Tetraether lipid liposomes protect macromolecular drugs from gastrointestinal degradation, enabling effective oral delivery to the liver.
- Bispecific Antibody Targeting EGFR and LGR5 for Gastric Cancer
A bispecific antibody binds extracellular domains of EGFR and LGR5 to inhibit tumor growth in gastric cancer models.
- Kidney Tonifying Nutritional Composition via Food-Medicine Homology
Composite nutritional composition balances curative efficacy against side effects by transforming concentrated herbs into palatable dietary grains.
- Lysophospholipid Bile Acid Conjugates Inhibit Bacterial Phospholipases
UDCA-LPE conjugates inhibit bacterial phospholipase activity to prevent pathogen invasion of the intestinal mucus barrier.