Dipeptide Ingredients TRIZ Cases
- Auristatin Analog Compositions for Higher-Potency Tumor Cell Killing
Modified auristatin compounds restore potency while preserving anti-mitotic activity to inhibit tumor growth and kill cancer cells.
- Atoh1 Protein Stabilization for Sensorineural Hair Cell Differentiation
Stabilizing Atoh1 by inhibiting proteasome degradation and related epigenetic pathways helps regenerate sensorineural hair cells for hearing loss.
- FLT3-ITD+ AML Combination Therapy Using ATRA, ATO, and Bortezomib
Low-dose ATRA, ATO, and Bortezomib combine ER stress, oxidative stress, and proteasome inhibition to kill FLT3-ITD+ AML cells with lower toxicity.
- Pimobendan Combination Composition for Animal Pulmonary Hypertension
A four-drug animal formulation improves cardiac output, lowers pulmonary pressure, and helps prevent right heart failure.
- Engineered NK Cell Therapy for Liver Tumor Targeting
Intra-hepatic delivery of engineered NK cells improves liver tumor targeting, boosts cytotoxicity, and limits off-target toxicity.
- Sardine Peptide Composition for Allergic Rhinitis Without Nasal Irritation
Short sardine peptides inhibit mast cell degranulation and inflammation to relieve allergic rhinitis without irritation, dryness, or drowsiness.
- ATAD1 Biomarker Selection for Proteasome Inhibitor Cancer Therapy
Genetic screening for ATAD1 loss identifies cancers more susceptible to proteasome inhibitors, improving apoptosis targeting and treatment use.
- Bifunctional Ligands for Induced Protein-Protein Binding Potency
A WA-C-WB bifunctional ligand recruits two proteins into one complex, boosting binding potency for targets that lack deep binding pockets.
- PRX3 Inhibitor Thiazole Acrylates With Better Solubility
Novel thiazole acrylate PRX3 inhibitors address thiostrepton insolubility and synthesis complexity while retaining cancer cell killing activity.
- Gamma-Secretase Inhibitors for RDEB Fibrosis Suppression
Blocking Notch signaling with gamma-secretase inhibitors reduces collagen deposition and fibrotic markers in RDEB fibroblasts.
- Zinc Salt and Cyclo-Hispro Composition for Respiratory Cytokine Control
A zinc salt and cyclo-hispro blend reduces allergic cytokines and mucus secretion to treat respiratory disease with fewer side effects.
- Bifunctional EGFR Degradant for Mutation-Resistant Lung Cancer
A bifunctional PROTAD compound degrades EGFR via ubiquitination to overcome mutation-driven resistance and suppress tumor progression.
- Unit-Dose Gut Health Composition for Inflammation and Microbiota Balance
A nine-ingredient unit dose targets gut inflammation, microbiota imbalance, and intestinal barrier weakness to improve gastrointestinal health.
- Engineered NK Cell Immunotherapy for Poor Liver Tumor Infiltration
Engineered NK cells with cytotoxic receptors and local liver delivery improve tumor infiltration and killing in liver tumors.
- Growth Factor Receptor Agonist Association for Neoplastic Cell Conversion
Activating growth factor receptors with a bioactive carrier converts neoplastic cells toward functional states while limiting healthy-cell damage.
- IBAT Inhibitors for Blocking Bile Acid Re-Absorption in Liver Disease
Selective IBAT inhibition blocks ileal bile acid re-absorption, lowering bile acid burden and improving liver histology and function.