Emulsion Delivery TRIZ Cases

Partial coating on hydrophilic nanoparticle supports improves T1 MRI contrast while maintaining dispersion stability across salt, pH, and temperature.

Precipitation, filtration, and redissolution remove toxic SABRE solvents and catalysts to produce biocompatible hyperpolarized contrast solutions.

An oil-in-water oral film disperses lipophilic actives in carrier oil to improve stability, retention, and bioavailability at high oil loading.

Partial coating on hydrophilic support particles improves T1 MRI nanoparticle dispersion stability while preserving high contrast ability.

Using PPSU20 homopolymers in a DMSO/water system enables stable nanogels with controlled morphology and high loading for hydrophobic and water-soluble cargo.

See how crosslinked dextran–iron nanostructures support T1 MRI contrast while avoiding macrophage uptake and enabling renal excretion.

PHIP converts propylene and parahydrogen into hyperpolarized propane near the scanner, avoiding costly on-site infrastructure for MRI contrast.

Stable water-in-oil microemulsions support extended transdermal drug delivery.

Segmenting ophthalmic emulsions into high area-to-volume chambers preserves physical structure while distinguishing fast and slow drug release processes.

Metal core nanoparticles coated with polyethylene glycol and polylactic acid coblock polymers provide stable magnetic resonance contrast agents.

Hydrophilic PEG coatings resolve hydrophobic core contradictions, allowing efficient proton exchange and safe in vivo tracking.

Protein polymer-gold nanoparticles coordinate via histidine tags to stabilize and deliver small molecules like curcumin.

A block copolymer with a zwitterionic core and stimulus-responsive terminal blocks forms reversible gels in aqueous solutions.

Fat emulsion dialysate removes albumin-bound toxins like p-cresol sulfate without consuming human albumin resources.

USPIO nanoparticles self-assemble into submicrometric clusters embedded in a polycathecolamine matrix to enhance magnetic signal intensity.

Segmented branched peptides self-assemble into nanofibers to deliver drugs to mitochondria while minimizing matrix toxicity.

PEG-alkyl nanoparticle formulations solubilize indocyanine green via micelle formation, preventing molecular aggregation and extending plasma circulation time.

Nanoemulsion with segmented hydrophobic and hydrophilic particles delivers active agents to hair follicles.

Weak organic acids and fatty acids form acidified micelles that improve transdermal drug penetration through the stratum corneum.

A method precipitates excess gadolinium as insoluble oxide for filtration before adding defined DOTA chelator.

Microemulsion emulgel improves leflunomide solubility and skin absorption, reducing systemic toxicity risks.

Melanin nanoparticles coordinate paramagnetic ions and attach PEG chains to resolve toxicity and retention time trade-offs in MRI contrast agents.

Hydroxyethyl starch stabilizes Lipiodol and Idarubicin emulsions, reducing systemic passage while maintaining tumor targeting.

Polymerized amphiphilic micelles self-assemble to encapsulate hydrophobic therapeutic compounds within a stable lipophilic core.

Replacing invasive biopsies, this method uses intravenous magnetic nanoparticles to detect early immune rejection via MRI signal changes.