Fungi TRIZ Cases
- Aspergillus cadA Deletion Redirects Carbon Flux for Organic Acid Production
Genetically deleting the cadA gene in Aspergillus redirects carbon flux from itaconic acid to accumulate aconitic acid, bypassing harsh chemical synthesis.
- Non-acidified Fermented Milk via Two-stage Yeast Agitation
Two-stage fermentation using Saccharomyces cerevisiae BR14 resolves acidity trade-offs by reducing lactose content and improving protein digestibility.
- Treponema pallidum Long-Term In Vitro Culture System
Microaerobic co-culture system supports long-term logarithmic multiplication of Treponema pallidum using modified media and rabbit epithelial cells.
- Engineered Yeast Metabolic Pathway for Noscapine Production
Heterologous enzymes convert canadine to noscapine in engineered yeast, increasing production efficiency while managing metabolic pathway complexity.
- Recombinant Yeast Biosynthesis of CBC-Type Cannabinoids
Engineered yeast converts fatty acid substrates into cannabinoids using heterologous terminal synthases, replacing energy-intensive plant cultivation.
- Yeast Strain Glucose Xylose Co-Utilization TRIZ Case
Isomerase pathway mutations resolve cofactor imbalance to boost ethanol yield from mixed lignocellulosic sugars.
- Pichia Fermentation Process Omitting Glycerol Fed-Batch Stage
A Pichia fermentation process uses optimized glycerol batch culturing to reach high fungal concentration before methanol induction.
- HTP Genomic Engineering Platform for Filamentous Fungi
Automated genomic engineering platform integrates machine learning with molecular biology to accelerate fungal strain improvement.
- Nicotinamide Riboside Production in Genetically Modified Fungi
Genetically modified Thermothelomyces heterothallica overexpresses biosynthesis enzymes to secrete nicotinamide riboside.
- ω-Hydroxyl Fatty Acid Production via Alkane Oxidation
Engineered yeast with reduced degradation capacity converts alkanes to omega-hydroxyl fatty acids, avoiding costly chemical catalysts and harsh conditions.
- Acetylated Sphingoid Base Production via Starmerella Bombicola Fermentation
Starmerella bombicola produces acetylated sphingoid bases using xenogeneic genes encoding polypeptides with acetyltransferase activity.
- Yarrowia Lipolytica GPI7 Deletion for Heterologous Protein Secretion
Removing the gpi7 gene from Yarrowia lipolytica resolves the trade-off between cell wall integrity and extracellular productivity, doubling secretion yields.
- Aspergillus aculeatus Mutant Strain for High Enzyme Production
Chemical induction of Aspergillus aculeatus E14-292 increases cellulase and xylanase productivity, resolving high production costs.
- Ergosterol-Free Yeast Feed for Honey Bee Brood Production
Ergosterol-free yeast compositions enhance brood production and survival rates while reducing Nosema infections in honey bee colonies.