Fungi TRIZ Cases

C10 human monoclonal antibody neutralizes FGF23, reducing dosing burden and immunogenicity risks in hypophosphatemia treatment.

Replacing the acyltransferase domain in Schizochytrium sp. resolves low EPA content control while maintaining high biomass yields.

Engineered microbes co-produce 1,4-butanediol and gamma-butyrolactone using metabolic engineering to replace petrochemical synthesis.

Wickerhamomyces anomalus CGMCC NO. 12416 lowers urea output to minimize ethyl carbamate formation in fermented foods.

A conidia-containing preparation with C3-6 polyol and alkaline salt provides a stable fungal inoculum source.

An auto-fill syringe system serially inoculates liquid mycelium culture from a temperature-regulated vessel.

Recombinant fusion proteins combine catalytic domains to produce complex N-glycans in fungal cells.

Orthogonal aminoacyl-tRNA synthetases incorporate non-naturally encoded amino acids into proteins, overcoming low yields from chemical aminoacylation.

Continuous cultivation of Trichocomaceae fungi achieves 57% crude protein content, reducing production costs compared to soy protein.

Engineered yeast strains ferment glucose to produce olivetol and olivetolic acid, resolving scalability bottlenecks in cannabinoid precursor synthesis.

Selective breeding creates yeast strains resistant to organic acids and salts, maintaining high alcohol yields in toxic environments.

A Schizosaccharomyces pombe transformant introduces a lactate dehydrogenase gene to produce lactic acid.

Iterative mutagenesis relieves antagonism between xylose utilization and inhibitor robustness, achieving a sugar-alcohol conversion rate of 0.43 g g−1.

Segmented inert gas injection and oxygen-absorbing packets preserve fermenting power by maintaining low oxygen levels at atmospheric pressure.

A recombinant beta-glucosidase antigen expressed in Uncinocarpus reesii enables sensitive immunodiffusion testing.

Segmented genetic pathways remove harmful intermediate accumulation, enabling faster furan-2,5-dicarboxylic acid production.

Microbial lipase engineering shifts substrate specificity toward short chain fatty acid release, resolving the soapy taste trade-off in dairy applications.

Incubating inulin with specific yeast species reduces free sugar content while maintaining fiber integrity and lowering processing costs.

Replacing organic filters with ceramic membranes eliminates enzyme retention, resolving the trade-off between production cost and separation yield.

Recombinant yeast produces lactic acid via pH shift, eliminating expensive acidification and salt removal steps required by conventional purification.