Genetically Modified Cells TRIZ Cases
- CAR-T Cell Preparation With Antigen Depletion and CD4/CD8 Selection
Depleting target antigen-positive cells before CD4/CD8 selection yields more uniform CAR or TCR-modified cells with better persistence and lower fratricide risk.
- Myogenic Cell Co-Culture Using Support Cells for Higher Myotube Yield
Engineered support cells in co-culture boost myotube formation, cell density, and muscle protein expression for scalable cell-based meat production.
- Notch Ligand Surface-Area Culture for Scalable T Cell Differentiation
Defined DL4 surface-area culture replaces heterogeneous feeder cells to scale homogeneous CD4-CD8+ T cell lineage generation.
- γδ T Cell Expansion With IL-15 for Solid Tumor Cytotoxicity
αβ T cell depletion plus anti-CD3 and IL-15 culture without IL-4 expands γδ T cells while preserving solid tumor killing activity.
- MicroOrganoSphere Droplet Culture for Rapid Precision Oncology Testing
Droplet microfluidics turns low-volume tumor tissue into MicroOrganoSpheres that preserve stromal cells and predict drug and immunotherapy response within 14 days.
- Anti-CD112R Antibody CDR Combinations for Checkpoint Blocking
Specific CDR combinations improve CD112R binding and blockade of CD112 interaction, boosting immune cell activation and tumor killing.
- Thymic Epithelial Progenitor Culture for In Vitro Maturation
Prolonged culture matures thymic epithelial progenitors in vitro, avoiding grafting for T cell-supporting cell production.
- Hypothermic In Vitro Stem Cell Cultivation for Pluripotency
Controlled cooling at 0–15°C enriches stem cells while preserving viability and pluripotent potential during in vitro cultivation.