Genetically Modified Cells TRIZ Cases
- ADAM17-Deficient NK Cells for Enhanced Cytotoxicity
ADAM17-deficient natural killer cells derived from induced pluripotent stem cells demonstrate increased cytotoxicity against tumor targets.
- Induced Hepatocyte Reprogramming via Transcription Factor Modulation
Converting non-hepatocytes to functional induced hepatocytes via transcription factor modulation overcomes primary cell scarcity for drug development.
- Pluripotent Stem Cell Differentiation Control via Cytotoxic Gene Engineering
Engineered pluripotent stem cells express tissue-specific cytotoxic genes to prevent unwanted differentiation into predetermined cell types.
- WAYNE293 Cell Adapted to Serum-Free Suspension Culture
A WAYNE293 cell line engineered for high-density suspension growth in serum-free media.
- Co-culture Lymphoid Tissue Equivalent for Predictive Immune Testing
A co-culture lymphoid tissue equivalent combines T cells, B cells, and antigen-primed dendritic cells to model human immune responses in vitro.
- Non-Static Bioreactor for T Cell Culture Scale-Up
A non-static bioreactor enables scalable T cell expansion using varying rocking rates.
- ETV2 Reprogrammed Endothelial Cells for Scaffold-Free 3D Blood Vessels
ETV2 transcription factor reprograms endothelial cells to self-assemble into stable vessels, eliminating scaffold complexity and perfusion requirements.
- Pluripotent Stem Cell Maintenance via ALK5 and MEK Inhibition
Adding specific inhibitors to the medium prevents differentiation pathways, enabling stable self-renewal of rat embryonic stem cells.