Glycosyltransferases TRIZ Cases
- Alternansucrase Enzyme Composition for Lower Glucose Uptake Without Taste Loss
Alternansucrase converts sucrose into slowly digestible glucan fibers in the gut, lowering glucose uptake while preserving food taste.
- GalNAc-siRNA B4GALT1 Inhibition for Type 2 Diabetes
GalNAc-conjugated siRNA silences B4GALT1 to overcome weak small-molecule inhibition and lower LDL, fasting glucose, and fibrinogen.
- B4GALT1 Variant Detection and Modulation for Cardiovascular Risk
Detecting B4GALT1 variants such as rs551564683 helps identify cardiovascular risk and guide therapies that lower serum lipids and fibrinogen.
- Non-Transgenic SBEII Mutations for Wheat Resistant Starch
Non-transgenic SBEII mutations combine across wheat homoeologous genes to overcome redundancy and raise amylose and resistant starch.
- GalNAc-Conjugated siRNA Inhibitors for B4GALT1 Silencing
GalNAc ligands help deliver siRNA to liver cells while B4GALT1 gene silencing modulates glycosylation for diabetes treatment.
- Pichia Pastoris Strains With Mutant OCH1 for N-Glycan Homogeneity
Mutant OCH1 alleles help Pichia pastoris produce 50–95% homogeneous N-glycans while preserving strain stability across generations.
- B4GALT1 siRNA Inhibitors for Targeted Gene Silencing
Traditional small-molecule inhibition is inadequate for B4GALT1-related diabetes; GalNAc-conjugated siRNA reduces its expression.
- B4GALT1 Serine-352 Variant Detection for Cardiovascular Risk
This case isolates B4GALT1 serine-352 sequences for rapid variant detection linked to lower LDL cholesterol and cardiovascular risk.
- Stable Pichia Pastoris Strains with Mutant OCH1 for Homogeneous N-Glycans
A mutant OCH1 pathway and α-1,2-mannosidase produce Man5GlcNAc2 glycans in stable Pichia pastoris strains.
- Viable Gal Knock-Out Sheep for Implant Antigen Screening
A viable GGTA1 knock-out sheep model screens biological implants for Gal antigen, helping reduce antibody-mediated rejection risk.
- Mutated CESA Polypeptides for Plant Herbicide Tolerance
Specific CESA mutations reduce herbicide binding while preserving cellulose biosynthesis in treated plants.