Heavy Metal Compound Active Ingredients TRIZ Cases
- NNMT Inhibitors for Targeting Cancer-Associated Fibroblasts
Inhibiting NNMT reverses the supportive phenotype of cancer-associated fibroblasts, lowering tumor burden and overcoming therapy resistance.
- Rhodium Metalloinsertor Selective DNA Mismatch Targeting
A rhodium metalloinsertor complex binds selectively to DNA mismatches through steric displacement of mismatched bases.
- Bismuth-Thiol Composition for Osteomyelitis Biofilm Eradication
Local bismuth-thiol delivery eradicates antibiotic-resistant biofilms on orthopedic hardware, overcoming systemic antibiotic access limits.
- Artemisinin Drug Combinations Overcome Leukemia Resistance
Artemisinin and second agent combinations overcome drug resistance by targeting primary oncogenic drivers alongside compensatory survival pathways.
- Carbenoxolone Sodium Protects Auditory Hair Cells
Carbenoxolone sodium protects auditory hair cells from cisplatin-induced hearing loss, offering broad-spectrum prevention where standard antioxidants fail.
- Bax-activating small molecules for cancer therapy
Small molecule compounds bind to the hydrophobic groove of Bax protein to induce apoptosis, overcoming tumor cell resistance to existing therapies.