Hormone Peptides TRIZ Cases
- Unacylated Ghrelin Fragments Modulate Ghrelin Levels in Prader-Willi Syndrome
Unacylated ghrelin fragments decrease ghrelin concentrations and ratios, resolving efficacy and selectivity trade-offs in metabolic disorder treatments.
- Ghrelin Receptor Antagonists via N-Terminal Tripeptide Modification
N-terminal GlyMetAla tripeptide converts agonists into antagonists to inhibit food intake and growth hormone secretion.
- S-Alkylated Hepcidin Peptides for Iron Overload Stability
S-alkylated hepcidin peptides modify reactive thiol groups to prevent oxidation, addressing iron overload disease side effects.
- BMP2-MIS Chimera Protein for Ovarian Cancer Apoptosis
Grafting MIS binding regions onto BMP2 frameworks creates recombinant proteins that overcome chemoresistance by inducing apoptosis in ovarian cancer cells.
- Liquid Protein Stabilization via Choline Dihydrogen Phosphate
Choline dihydrogen phosphate preserves therapeutic proteins in liquid state, eliminating lyophilization complexity and reducing manufacturing costs.
- Intralumenal Drug Delivery Device with Electrically-Actuated Permeation
An intralumenal device uses an electrically-actuatable portion to disrupt the mucosal barrier for enhanced drug transfer.
- SAR-BRI Sequence Enhances Recombinant Protein Expression Stability
A 70 bp SAR-BRI sequence from interferon alpha-2 stabilizes recombinant protein expression in mammalian cells.
- Yeast KEX1 Gene Disruption for Intact C-Terminal Glycine
Disrupting the KEX1 gene in yeast preserves C-terminal glycine integrity, enabling efficient conversion to biologically active alpha-amidated peptides.
- hAM15-52 Analogues for Amylin Receptor Potency and Stability
Targeted amino acid substitutions in hAM15-52 analogues improve amylin receptor potency and metabolic stability, reducing fibrillation tendency.
- Mini-hepcidin Peptides for Iron Overload Treatment
Segmented hepcidin peptides mimic natural hormone activity by binding ferroportin, reducing patient burden from phlebotomy.