Hormone Peptides TRIZ Cases
- Hybrid Polypeptides for Metabolic Disease Treatment
Exendin-4 fused with amylin via Gly linkers extends serum half-life, resolving the trade-off between therapeutic reliability and administration frequency.
- HIV-1 Protease Inhibitor Screening via Resistin Polymorphism Detection
Resistin degradation assays detect metabolic abnormalities caused by HIV-1 protease inhibitors, enabling personalized treatment selection.
- Recombinant EPO with Glycosylated Peptide for Half-Life Extension
Fusing erythropoietin with a highly glycosylated peptide creates a recombinant protein with extended plasma half-life.
- Unacylated Ghrelin Fragments for Metabolic Disorder Treatment
Segmenting full-length peptides into minimal active sequences reduces immunogenicity while maintaining therapeutic efficacy.
- Angiotensin-(1-9) Peptide Therapy for Cardiovascular Remodeling
Elevating angiotensin-(1-9) levels via ACE2 expression or direct administration reduces pulmonary and renal remodeling.
- Soluble ActRIIa Antagonists for Bone Density and Strength
Soluble ActRIIa antagonists resolve side effects from existing therapies by modulating osteoclast and osteoblast balance.
- Relaxin Hydrogel for Stiffened Joint Treatment
Intra-articular relaxin hydrogel degrades fibrotic collagen to resolve prolonged recovery from stiffened joints.
- GnRH Agonist Peptide Modulates Hormone Secretion
Novel GnRH agonist peptides reduce treatment side effects while effectively controlling sex hormone concentrations.
- Adrenomedullin Derivative Medicament for Viral Infection Treatment
Adrenomedullin derivative medicament treats viral infections while minimizing vasodilatory side effects via modified peptide structures.
- Recombinant hCG Sialylation for Pharmacokinetic Profile
Human cell-derived recombinant hCG with enhanced sialic acid content extends plasma half-life and bioactivity compared to CHO-produced products.