Microencapsulation Based TRIZ Cases
- Circular RNA CAR Constructs for In Vivo Cancer Cell Targeting
Circular RNA delivered with lipid vehicles enables in vivo CAR expression, reducing lymphodepletion, procedure complexity, and toxic side effects.
- Copolypeptide Nucleic Acid Carrier for Stable Gene Delivery
A branched peptide carrier uses charged and hydrophobic segments to protect nucleic acids, improve cell uptake, and reduce cytotoxicity.
- Ionizable Lipid Composition for pH-Responsive Nucleic Acid Delivery
pH-responsive ionizable lipids stay less toxic in circulation and become cationic in endosomes to improve nucleic acid transfection.
- Anionic Shielding Polymer Complexes for Stable Non-Viral Delivery
An anionic methionine sulfoxide copolymer shields cationic gene carriers to reduce aggregation and immune response without sacrificing uptake.
- Cardiopoietic Stem Cell Induction Using Microencapsulated mRNA
Microencapsulated mRNA delivery of mesodermal factors enables 5-day cardiopoietic stem cell generation with lower cost and less protocol variability.
- Lipid Particle Enhancer for CAR-T Antigen Loss Escape
Lipid particles deliver antigen and costimulatory genes to tumor cells, restoring CAR-T recognition when antigen expression fades.
- Hydrophobic Oligonucleotide Loading for Scalable Exosome Delivery
Hydrophobic oligonucleotide modification enables simple exosome incubation with over 80% loading efficiency and scalable therapeutic production.
- CuAAC Ligand Chemistry for Low-Toxicity Live-Cell Labeling
A CuAAC-accelerating ligand enables live-cell biomolecule labeling at lower copper levels, improving biocompatibility and reaction sensitivity.
- CAR Antigen Re-Expression Enhancer for Sustained CAR-T Killing
Lipid particles deliver CAR antigen and costimulatory genes to tumor cells, restoring recognition and sustaining CAR-T therapy over time.
- Polylactic Acid Salt Nanoparticle Kit for Stable On-Demand Drug Encapsulation
Separate chambers keep cationic and polymer components stable until mixing, enabling easy formation of drug-loaded nanoparticles at use.
- mRNA Antibody Delivery via Liposomes for Safer In Vivo Expression
Liposome-encapsulated mRNAs encoding antibody chains enable systemic in vivo antibody production while avoiding DNA persistence risks.
- CRISPR Guide Library Design for Targeted Gene Coverage
Ranks guide sequences by on-target and off-target scores to build custom CRISPR libraries with focused gene coverage and fewer cells.