Microorganism Based Processes TRIZ Cases
- Modified Microbial Host Cells for Recombinant Protein Production
Modifying microbial host cells reduces endogenous protease activity and alters transcription regulators, increasing recombinant protein stability.
- Recombinant Yeast Glycerol Uptake and Redox Balance
Engineering recombinant yeast with STL1 importers and formate pathways reduces glycerol by-products while maintaining anaerobic growth reliability.
- MetA10 Mutant E. coli for O-Succinylhomoserine Production
Deleting metB and introducing MetA10 mutations bypasses methionine feedback inhibition and cystathionine side reactions to boost precursor yield.
- Enzyme-Modified Submerged Fermentation Broth Viscosity
Adding muramidase or chitinase degrades polysaccharides in the fermentation broth, reducing viscosity to improve oxygen transfer and productivity.
- Galactoside O-Acetyltransferase Variant for L-Glutamic Acid Yield
A galactoside O-acetyltransferase variant with a leucine-to-phenylalanine substitution enhances enzymatic activity in Corynebacterium glutamicum.
- Ni-Al2O3-SiO2 Catalyst for Direct Microalgae Conversion
A nickel on silica/alumina catalyst formulation enables direct conversion of wet microalgae into biofuels without harvesting.
- Microorganism Gene Modification for 5'-Guanylic Acid Yield
Targeted gene modification increases GMP yield while preventing product degradation during industrial fermentation.