Nervous Disorder TRIZ Cases
- Pyrazolotriazine Nuclease Inhibitors for DNA Repair Disruption
Substituted pyrazolotriazine compounds inhibit MUS81 and MRE11 nucleases to disrupt DNA repair mechanisms in cancer cells.
- Peptide Formulations Using Cyclodextrin Inclusion Complexes
Cyclodextrins encapsulate lipophilic peptides to create stable aqueous solutions with high drug concentrations.
- Memantine Synthesis via N-chloro-acetylamino Intermediate
Using N-chloro-acetylamino-3,5-dimethyladamantane as an intermediate resolves high temperature and long reaction time bottlenecks in memantine synthesis.
- Topical Peptide Composition for Multiple Sclerosis Treatment
A topical peptide mixture reduces disease progression and relapse frequency in multiple sclerosis patients.
- Low-Dose X-Ray Irradiation for Motor Function Recovery in TBI
Low-dose X-ray irradiation reverses irreversible motor deficits by reducing growth inhibitory extracellular matrix deposition.
- Halo-(3-(phenylsulfonyl)prop-1-enyl)pyridine derivative for Nrf2 activation
A halo-(3-(phenylsulfonyl)prop-1-enyl)pyridine derivative activates the Nrf2 pathway to treat oxidative stress diseases.
- Lysine-Deficient Arginine Deiminase Mutant for PEG Modification
A genetically modified arginine deiminase mutant with specific lysine substitutions enables controlled polyethylene glycol conjugation.
- IL-23p19 Antagonist Combination Therapy for Autoimmune Disorders
Combination therapy with IL-23p19 antagonists targets Th17 cells to manage autoimmune disorders.
- Sigma Receptor Ligands for Post-Surgical Pain Relief
Sigma receptor ligands target sigma receptors to relieve post-surgical pain without opioid side effects.
- Clonal Stem Cell Selection for Homogeneous Differentiation
A clonal selection method isolates individual pluripotent cells to expand homogeneous populations of neural, hepatic, or cardiac lineages.
- GLP-1 Albumin Fusion for Sustained Glucose Control
Fusing GLP-1 with human serum albumin extends circulation time, reducing injection frequency while maintaining effective glucose control.
- Purifying TACI-Fc Dimers Using Protein A Oilbodies
Replacing costly chromatography, protein A oilbodies purify TACI-Fc dimers with high selectivity and reduced process complexity.
- Monovalent Anti-CD40L Antibody Polypeptides Preventing Cross-Linking
Segmenting the antibody into a monovalent variable domain prevents cross-linking side effects while PEGylation extends half-life and reduces immunogenicity.
- Lactobacillus plantarum PS128 for Rett Syndrome Symptom Management
Administering Lactobacillus plantarum PS128 addresses palliative treatment limits by improving cognitive and motor functions while reducing dystonia symptoms.
- C-Terminus Antibodies for Selective Amyloid Plaque Clearance
Targeting the C-terminus epitope clears plaques while minimizing cerebral hemorrhage and inflammation risks.
- IL-2 Fusion Molecule Selective Treg Stimulation
Masking moieties block IL-2Rβ and IL-2Rγ binding, preventing non-specific immune activation.
- Antibodies Targeting NK Cell Receptors for Immunoproliferative Disorder Treatment
Antibodies bind NKG2A and NKG2C receptors on natural killer cells to trigger antibody-dependent cellular cytotoxicity.
- D-serine Antagonism of GluN3 NMDARs for Seizure Control
D-serine antagonizes GluN3-containing triheteromeric NMDARs, inhibiting calcium ion uptake and reducing seizure frequency without neurotoxicity.
- Arimoclomol Therapy for ER Type Missense Mutations in Niemann-Pick Disease
Arimoclomol combined with miglustat treats Niemann-Pick disease type C patients with ER type missense mutations by promoting proper protein folding.