Oncogene Translation Products TRIZ Cases
- MAVS Protein Overexpression for Refractory Tumor Immunosuppression
Overexpressing MAVS alters the immunosuppressive tumor microenvironment, enabling effective immune checkpoint blockade therapy.
- Brachyury Protein Vectors Induce T Cell Response
Engineered dendritic cells present Brachyury antigens to activate tumor-specific T cells, overcoming resistance in conventional cancer therapies.
- Stapled Peptides Inhibit KRAS-Raf Binding
Stapled peptides target the Raf RBD helical domain to block mutant Kras binding, resolving specificity and effectiveness trade-offs.