P53 Protein TRIZ Cases
- Mutant p53 Co-Crystal Compounds for DNA-Binding Recovery
Hydrogen-bonding compounds from mutant p53 co-crystal structures stabilize Y220C-like variants, recover DNA binding, and trigger apoptosis.
- OmniTAC Protein Recruiters for Targeted Intracellular Modification
OmniTAC compounds link a target protein to a modifier protein to drive specific intracellular modification and reactivate disease-associated proteins.