Peptide Libraries TRIZ Cases
- Genetically Encoded Bicyclic Peptide Libraries With Aqueous Linker Cyclization
Two-fold symmetric linkers create blocked-terminus bicyclic peptides in aqueous conditions, reducing proteolytic cleavage during library screening.
- Cyclic Peptide Library Screening with Segmented Co-Compartmentalisation
Segmented compartments simplify cyclic peptide screening without droplet fusion.
- Antibody Library Design Using Somatic Hypermutation Motifs
This case uses RGYW and WRCY motifs to build smaller antibody libraries with more improved-affinity variants.
- comPACT Peptide-MHC Complexes for Barcode-Based T Cell Isolation
Modular comPACT peptide-MHC scaffolds and barcode particle sets enable sensitive, high-throughput isolation of antigen-specific T cells.
- CAR Library Screening for Functional scFvs in CAR-T Cells
A CAR library integrates scFv selection with CAR-T cell testing, reducing nucleic acid requirements while confirming cellular activity.
- Antibody Libraries with Natural CDRs and Liability Screening
Natural CDRs and liability screening improve antibody library function.
- Antibody VL-VH Pairing Through Selection-Cycle Feature Analysis
Multiple biopanning cycles and sequencing feed a classification model that reconstructs VL-VH pairs from antibody gene counts.
- Spatial Analysis Hydrophobic Sealing for Analyte Isolation
Hydrophobic seals block analytes from non-interest regions, improving capture focus, sequencing depth, and spatial resolution.
- De Novo Binding Polypeptides for Cysteine-Free Target Recognition
This case uses linear, cysteine-free DBDpp sequences to avoid improper pairing while supporting specific binding, purification, and therapy.
- Macrocyclic Peptide Display Using Non-Reducible Thioether Bridges
Ribosomal incorporation of reactive amino acids enables stable macrocyclic peptide display and high-throughput library screening.
- Variant CH3 Domains for Preferential Bispecific Pairing
Specific CH3 substitutions favor heterodimer formation, improving bispecific antibody production and stability.
- Antibody Libraries With Liability-Filtered CDR Diversity
Natural CDR diversity is paired with selected frameworks to reduce liabilities, aggregation, and poor functional expression.
- Antibody Libraries: CDR Diversification for Functional Developability
Natural antibody CDRs, screened frameworks, and liability exclusion balance library diversity with functional expression.
- Human Vh3 Variable Heavy-Only Libraries for Lower Immunogenicity
M13 phage display screens diversified human Vh3 VHO domains to identify stable, specific binders with reduced immunogenicity.