Peptide-Nucleic Acids TRIZ Cases
- Engineered Synthetic Peptides for OPN-Targeted Glioma Immunotherapy
Engineered peptides block osteopontin interactions with macrophages and microglia, limiting glioma invasiveness and supporting anti-PD1 therapy.
- Synthetic Peptides for Respiratory Virus Inhibition in Epithelial Cells
Synthetic peptides target respiratory viruses in epithelial cells, addressing limited antiviral efficacy and adverse effects without disrupting cellular structures.
- Self-Assembling Polypeptide Nanoparticles for Oligonucleotide Delivery
This case addresses complex viral-like delivery systems with polypeptides that encapsulate oligonucleotides for cellular uptake.
- Synthetic P. vivax Antigens for DBPII-Mediated Erythrocyte Invasion
Synthetic antigens targeting the P. vivax DBPII ligand domain inhibit erythrocyte invasion while addressing drug-resistant strains and relapse risk.
- Tunable Synthetic Protein Circuits for Signal Thresholding
Modular polypeptide domains and tuner proteins set above- or below-threshold responses, controlling protein activity, stability, and localization.
- Tirzepatide Peptide Synthesis for High Purity and Lower Waste
Selective protection, nanofiltration, and organic coupling agents help produce high-purity tirzepatide with fewer purification steps and less waste.
- Tirzepatide Manufacturing Process for High-Purity, Low-Waste Synthesis
Novel protected intermediates, nanofiltration, and selective lysine acylation support high-purity tirzepatide with less waste.
- Collagenase-Derived ECM Peptides for Hair Follicle Neogenesis
Collagenase releases protease-resistant ECM peptides that stimulate new hair follicle formation and support wound healing during radiation treatment.
- Baseline Peptide Bioreceptor Design for Interference-Resistant Glucose Sensing
This case uses docking, molecular dynamics, and multi-parameter optimization to design stable peptide receptors for glucose biosensors.
- Bicyclic Peptide Inhibitors for Cell-Permeable NEMO–IKK Blocking
A dual-ring peptide architecture pairs cell-penetrating and NEMO-binding sequences to inhibit NEMO–IKK signaling.
- Cysteine Peptide Hair Shaping to Reduce Keratin Damage
Cysteine peptides form disulfide bonds with keratin to shape hair, reduce breakage, and retain effects after washing.
- Membrane-Penetrating Peptides for Difficult-Cell Transfection
Cationic lipid–peptide complexes improve nucleic acid delivery into difficult-to-transfect cells with low toxicity.
- Peptoid Polymer Cryoprotection for Low-Toxicity Organ Preservation
Hydrophobic and polar peptoid polymers inhibit subzero ice formation, supporting longer organ preservation with less tissue toxicity.
- Branched Degradable PEG Binders Balance Half-Life and Vacuolation
Branched PEG with intracellularly cleavable linkages preserves blood stability and half-life while reducing vacuole formation.
- Self-Assembling Protein Synthesis with γ-Cyclodextrin Host-Guest Assembly
Aqueous γ-cyclodextrin host-guest processing enables site-specific bioconjugation with less purification, supporting scalable SAP synthesis.
- De Novo Designed EpCAM and PDL1 Binders for Tumor Penetration
De novo polypeptides with optional linkers target EpCAM and PDL1 at nanomolar affinity while improving tumor penetration.
- GLP-1/GCG/GIP Triple-Receptor Agonist for Metabolic Disorder Control
This case combines GLP-1, GCG, and GIP activity in one polypeptide for glucose and weight control with weekly action.