Peptides TRIZ Cases

Specific RhDmpA3 mutations enable ATP-free imidazole dipeptide synthesis while improving thermal stability and lowering carnosine production cost.

A small-molecule feeder-free culture platform improves pluripotent cell reprogramming while limiting differentiation and preserving genomic stability.

Small molecules and dimers bind structured pre-miR-21 RNA to trigger cleavage, suppress cancer cell survival, and reduce metastasis.

Bifunctional compounds route extracellular proteins through ASGPR or M6PR endocytosis to lysosomal degradation, lowering plasma levels of hard-to-inhibit targets.

CD4+ T feeder cells enable selective NK cell expansion from small seed cultures while preserving viability and tumor-killing activity.

Gene inactivation and vector tuning raise D-psicose-3-epimerase output in Bacillus subtilis while supporting safety-compliant fermentation.

Localized PD-L1 hydrogel delivery helps protect allogeneic islet grafts, sustain insulin production, and avoid chronic systemic immunosuppression.

Selective aptamers detect neurofilament light in saliva, urine, blood, enabling earlier, low-cost, minimally invasive testing.

Targeted amino acid substitutions lower the general acid pKa in α-amylase, boosting activity at pH 8.5-10.5 for starch processing and stain removal.

A D-amino acid RK polypeptide dimer with 99mTc labeling improves HER2 tumor specificity and enables noninvasive trastuzumab response monitoring.

Zwitterionic linker chemistry improves radiopharmaceutical pharmacokinetics by lowering kidney retention and boosting tumor-to-tissue PET contrast.

Late-stage camptothecin incorporation improves yield and purity for scalable manufacturing while avoiding column chromatography and reducing toxic exposure.

Engineered host cells with optimized carotenoid enzymes raise single-isomer ionone and retinoid output without scarce extraction or mixed-isomer synthesis.

A nanopore membrane and copper-binding peptide enable fast, highly selective Cu2+ detection in fluids down to femtomolar levels.

A specific asbestos-binding peptide enables rapid on-site detection of chrysotile and amphibole fibers without complex microscopy.

Fermentation-derived momomycin offers a new colorectal cancer treatment route, combining strong growth inhibition with simpler microbial production.

Specific blood-derived peptides turn unpleasant livestock and poultry blood hydrolysates into salt, umami, and kokumi taste modulators.

Molecularly modified camptothecin payloads improve ADC anti-tumor activity while reducing toxicity and side effects that narrow the therapeutic window.

BΔg-targeting peptides cross the blood-brain barrier to improve glioblastoma imaging precision and selective drug delivery while sparing healthy tissue.

Hydrophilic linker chemistry lets ADCs carry higher hydrophobic drug loads while preserving antibody properties, lowering clearance, and widening therapeutic index.

Cyclic peptides use rigid disulfide-linked structures to cross the BBB and bind α-synuclein and IAPP, suppressing amyloid self-assembly.