Polymorphism Uses TRIZ Cases
- APOA1 Allele-Specific CRISPR Knockout for Amyloidosis
Guide RNAs target heterozygous APOA1 SNPs to knock out the mutant allele while preserving functional apoA-1 expression and limiting amyloid fibrils.
- Personalized CRISPR/Cas Complexes for MYD88-Mutant B-Cell Lymphoma
Customized guide RNA directs CRISPR/Cas to the MYD88 L265P mutation, killing B-cell lymphoma cells while sparing healthy cells.
- Allele-Specific ELANE Knockout for Severe Congenital Neutropenia
CRISPR guide RNAs selectively disable the mutant ELANE allele to treat SCN or CyN while preserving functional protein expression.
- Cytoactive RNA Modulation for Selective Cytoplasmic G4R1 Silencing
Selective RNA-targeting agents suppress toxic cytoplasmic G4R1 while preserving nuclear G4R1, reducing off-target cellular effects.
- Modified Antisense Oligonucleotides for SNP-Specific Target Binding
Chemically modified antisense oligonucleotides improve SNP-level target specificity while preserving effective nucleic acid modulation.
- Allele-Specific RNAi for PLN-R14del Cardiomyopathy
Selective siRNA silences the PLN R14del mutant transcript while preserving wild-type expression to improve cardiac function and lower arrhythmia risk.