Polypeptide With Localisation/Targeting Motif TRIZ Cases
- Mxra8-Targeted Fusion Proteins for Alphavirus Entry Inhibition
Target Mxra8 with Fc fusion proteins, antibodies, small molecules, or CRISPR editing to block alphavirus entry and reduce inflammation.
- CD8 Binding Agents for Non-Modulating Immune Cell Recruitment
CD8-binding VHHs recruit immune cells to tumor sites without functionally modulating CD8 signaling.
- Receptor-Binding Anti-Tau Fusion for Blood-Brain Barrier Delivery
A receptor-binding peptide carries an anti-tau antibody across the BBB, enabling brain delivery and inhibition of abnormal tau aggregation.
- Casσ RNA-Guided Endonuclease for Precise 5′-NTN Gene Editing
A Casσ RNA-guided nuclease uses a 5′-NTN PAM and functional domains to improve editing precision while limiting off-target effects.
- CD22-Δex5-6 Antibodies for Selective B-ALL Targeting
Low mutational burden and drug resistance limit B-ALL therapy; selective antibodies target the CD22-Δex5-6 splice variant.
- Molecular Guide System Peptide Conjugates for Intracellular Delivery
MGS peptide conjugation enables antibodies to enter cells and reach intracellular targets, supporting modulation of protein–protein interactions.
- Anti-ROR2 Antibody Specificity for Lower-Toxicity Tumor Targeting
Conservative amino acid substitutions tune anti-ROR2 variable regions for high-affinity tumor binding while reducing toxicity to normal tissues.