Powder Delivery TRIZ Cases
- sNAG Nanofibers Stimulate Defensin to Reduce Bacterial Loads
Shortened poly-N-acetylglucosamine nanofibers stimulate host defensin expression to reduce bacterial loads without triggering antibiotic resistance.
- Aprepitant Amorphous Solid Dispersion Solubility
Amorphous solid dispersion improves Aprepitant solubility while avoiding manufacturing complexity.
- Itraconazole Solid Dispersion Melt Extrusion Bioavailability
Melt extrusion creates a homogeneous itraconazole and hydroxypropyl methylcellulose solid dispersion for enhanced dissolution.
- Ionizable Cationic Lipid Analog Nucleic Acid Delivery
Ionizable cationic lipid analogs form stable complexes with nucleic acids for efficient intracellular delivery.
- Biomaterials for Combined Radiotherapy and Immunotherapy
Implantable biomaterials release immunoadjuvant-loaded nanoparticles to activate immune responses against tumors while minimizing damage to healthy tissues.
- SERS Nanotags with PEG Protective Coats for In Vivo Tumor Detection
Bifunctional polyethylene glycol linkers on gold SERS nanotags prevent direct biological molecule adsorption, ensuring reproducible signal detection in vivo.
- Tobramycin Sulfate Powder Spray Drying Process
Replacing lyophilization with aseptic spray drying reduces energy consumption while producing amorphous tobramycin sulfate powder suitable for intravenous use.
- Water-Soluble Up-Converting Nanoparticles via Dendrimer Surface Modification
Replacing hydrophobic ligands with ionic dendritic polymers enhances aqueous solubility and biocompatibility of up-converting nanoparticles.
- Antibody-Polymer Nanoparticulates for Circulating Chromatin Fragment Removal
Complexed antibody-substrate nano-particulates bind circulating chromatin fragments, reducing pathological burden without invasive ex-vivo procedures.
- Selective BRD4 Inhibitors Blocking Airway Inflammation
Selective BRD4 inhibitors block airway inflammation while avoiding blood-brain barrier penetration to prevent neurological adverse effects.
- Mitotane Dry Emulsion for Adrenocortical Carcinoma Treatment
A mitotane dry emulsion formulation using cyclodextrins enhances oral bioavailability through inclusion complex formation.
- 13-Glyceride Coix Seed Oil Composition for Tumor Treatment
Isolating 13 specific glycerides from Coix seed oil resolves quality control contradictions while enabling tumor cell inhibition.
- Sustained Release LAAM Formulations via Hydrophobic Ion-Pairing
Hydrophobic ion-pairing complexes associate with biodegradable polymeric microparticles to enable sustained release of levo-alpha-acetylmethadol.
- 17-OHPC Powder Particle Size Control via High-Pressure Homogenization
High-pressure homogenization reduces 17-OHPC particle size while preserving crystalline structure and minimizing contamination.
- Thyroid Hormone Dry Powder Inhalation Carrier Stability
Replacing lactose with non-reducing sugars stabilizes thyroid hormone dry powder, preventing degradation during long-term storage.
- Modified Platelet Delivery of Checkpoint Inhibitors for AML
Modified platelets deliver checkpoint inhibitors to bone marrow leukemia cells.