Protease Inhibitors TRIZ Cases
- Recombinant Alpha-1 Antitrypsin Glycosylation in Continuous Yeast Production
This case uses OCH1-engineered Pichia pastoris to secrete recombinant alpha-1 antitrypsin with homogeneous N-glycans.
- Tick Salivary Polypeptide Ir-CPI Contact Phase Inhibition
Ir-CPI polypeptide inhibits Factor XIIa and kallikrein activity to block thrombus formation without impairing primary hemostasis.
- CRISPR-Generated AAT Deficient Mouse Model for Lung Disease Screening
Transgenic mouse model lacking hepatic and circulatory AAT protein enables therapeutic compound screening.