Hashing and normalization oligos raise single-cell library throughput, improve doublet detection, and reduce technical noise at lower reagent cost.
Cas-gRNA ribonucleoproteins hybridize to target sequences and cut DNA to generate free ends, resolving oligonucleotide design complexity in epigenetic assays.
Systematic codon variation in nucleic acid libraries resolves the trade-off between chemical stability and cellular uptake efficiency.