Respiratory Disorder TRIZ Cases
- (S)-Enantiomer Chaperone for Selective Z A1AT Augmentation
A selective chaperone compound increases plasma levels of misfolded Z A1AT protein in vivo.
- Regorafenib Composition for COPD Immune Response Inhibition
Regorafenib modulates immune cell proliferation to suppress inflammatory mediators, addressing insufficient efficacy and side effects of current COPD therapies.
- AAV Viral Vectors Modulating miRNA for PF-ILD Treatment
Adeno-associated virus vectors deliver microRNA mimetics to modulate fibrotic pathways in progressive interstitial lung disease.
- DNA Ligase IV and PARP Inhibitor Combination for Cancer Therapy
Synergistic DNA ligase IV and PARP inhibitor combination targets drug-resistant cancers by blocking multiple DNA repair pathways.
- Imatinib Mesylate Tablet Coating for Polymorphic Stability
Low-water organic solvent coating prevents imatinib mesylate polymorphic conversion during storage, ensuring drug efficacy.
- Ganciclovir for Intractable Allergic Rhinitis via Immune Regulation
Ganciclovir treats intractable allergic rhinitis by regulating immune balance, increasing regulatory T cells to restore routine medicine efficacy.
- PDE4 Inhibitor and CFTR Corrector Combination for Cystic Fibrosis
Combining PDE4 inhibitors with CFTR correctors treats cystic fibrosis by activating channels across diverse mutations.