Senses Disorder TRIZ Cases
- Tromethamine Salt of Bimatoprost Acid Crystalline Form
Crystalline tromethamine salt of bimatoprost acid prevents precipitation in ocular solutions, maintaining drug potency and bioavailability.
- Boronate Ester Compounds for Stable Proteasome Inhibition
Boronate ester compounds maintain proteasome inhibition while preventing cyclic trimeric anhydride formation and air-sensitivity.
- Water-Soluble Cyclosporin Analogs for Dry Eye
Novel water-soluble cyclosporin analogs inhibit cyclophilin to treat ocular conditions.
- Chitosan Protective Coating Sprayability and Stability
Segmented crosslinking enables sprayable chitosan application while preventing premature runoff from treatment sites.
- SIRPα-VEGFR1 Fusion Protein for Dual CD47 and VEGF Targeting
A recombinant fusion protein links SIRPα to VEGFR1 via an Fc fragment to bind CD47 and VEGF simultaneously.
- Imidazolo-oxazolo-thiazolopyrimidine TRPV1 Modulators
Imidazolo-, oxazolo-, and thiazolopyrimidine derivatives modulate TRPV1 activity.
- Amide-Substituted Indazole Salts for Selective PARP Inhibition
Amide-substituted indazole salts resolve weak inhibitory activity and off-target effects by achieving high selectivity for BRCA-deficient cancer cells.
- Fused Pentacyclic Imidazole Derivatives for TNFα Modulation
Fused pentacyclic imidazole derivatives neutralize TNFα signaling while minimizing adverse cardiovascular side-effects and metabolic clearance.
- Selective FXR Agonists for Dyslipidemia Treatment
Selective FXR agonists resolve the trade-off between efficacy and selectivity by optimizing molecular structures to improve lipid profiles.
- Clostridial Neurotoxin Activation via Bovine Trypsin
Bovine trypsin converts single-chain clostridial neurotoxins into di-chain forms for downstream purification.
- Oxo-Substituted Boronic Acid Compound for Broad-Spectrum Beta-Lactamase Inhibition
Novel oxo-substituted boronic acid compound inhibits beta-lactamases through specific molecular structure.
- L-Cysteine Capsule for Alcohol Flushing Prevention
Slow-release L-cysteine capsules bind acetaldehyde in the stomach, preventing local histamine release that causes facial redness and hypersensitivity.
- Thiazole Inner Salt for Stable AGE Inhibition
Stable thiazole inner salt monohydrate breaks down advanced glycation end products.
- MLPSC Therapy for Ocular Disease Visual Acuity
Intravitreal MLPSC injections protect photoreceptors and reduce inflammation, improving visual acuity beyond anti-VEGF neovascularization control.