Solution Delivery TRIZ Cases
- Sorafenib Particles Supercritical Processing
Supercritical fluid extraction and sonic energy treat sorafenib droplets to increase specific surface area, resolving poor aqueous solubility.
- Quinolone Ophthalmic Suspension Stability
Ionic and non-ionic suspension agents combined with chelating agents prevent flocculation in ophthalmic formulations.
- Co-processed Lubricant MCG for Tablet Hardness and Flow
A co-processed excipient combines microcrystalline cellulose with magnesium stearate to improve tablet hardness.
- Lactobacillus pentosus and Zinc Composition for Chemotherapy Support
A composition using Lactobacillus pentosus and internalized zinc to stimulate immune cytokine production.
- Polymer Melt Polycondensation for Injectable Bioactive Delivery
Melt polycondensation of 2-hydroxyalkyl acids creates polymers that overcome solid aggregate formation and enable direct bioactive agent formulation.
- Liposome Encapsulation for Injectable Cold Slurry Sterility
Pre-frozen liposome cores enable sterile, flowable cold slurries without complex point-of-care manufacturing equipment.
- Dapansutrile NLRP3 Inhibition Cardiovascular Disease Treatment
Dapansutrile targets the NLRP3 inflammasome pathway to resolve inadequate inflammation management and prevent complications in acute myocardial infarction.
- Biodegradable Drug Delivery via Block Copolymer Implant
Block copolymers self-assemble into micelles to solubilize hydrophobic drugs, forming in situ implants that reduce burst release and improve bioavailability.