Sonopheresis TRIZ Cases

A mixed-micelle topical composition improves skin penetration to reduce localized fat without surgery, injections, or prolonged recovery.

Stem cell-bound CNT or gold drug carriers improve tumor targeting and drug retention under blood and acidic pH conditions while limiting side effects.

Alternating low and high ultrasound mechanical index boosts nucleic acid transfection, improves gene expression, and limits cellular damage.

Specific alternating electric field frequencies temporarily open cancer cell membranes, improving large-molecule delivery in glioblastoma treatment.

Anodal iontophoresis co-delivers NAD+ and therapeutic peptides through skin to extend regenerative effects with minimal irritation.

Non-bubble sonoporation uses ultrasound to open cell membranes locally, improving chitosan nanoparticle drug delivery while reducing normal-cell toxicity.

Bi-phasic microbubble and microdroplet clusters raise drug loading, resist washout, and enable lower-power ultrasound delivery with less vascular damage.

High-voltage electroporation opens temporary membrane pores so Gelonin can enter mammalian cells and achieve stronger targeted cytotoxicity.

Submicron light-absorbing particles reach hair follicles by topical application and agitation, then use energy activation for targeted acne treatment.

PLGA-shelled microbubbles extend half-life while enabling controlled ultrasound cavitation for therapy with fewer injections and less tissue damage.

Internalized magnetic nanoparticles create temporary membrane pores under a magnetic field, boosting drug uptake without electrode contact.

Bi-phasic microbubble-microdroplet clusters enable low-power ultrasound activation, higher drug loading, and longer target-site retention.

miRNA and mRNA profiling guides IL-12, hTERT/WT-1/PSMA, and anti-PD-1 therapy to improve survival in brain cancer.

Mechanical agitation and ultrasound move light-absorbing submicron particles into follicles for localized thermal treatment.

Alternating electric fields temporarily increase cancer cell membrane permeability, helping nanoparticles enter and improve imaging of micro-metastases.

Recombinant IL-21 strengthens cellular and humoral vaccine responses across antigens and muscle or skin delivery routes.

Electric or ultrasonic energy permeabilizes target cell membranes so neurotoxin light chains can act while limiting off-target toxicity.

See how engineered oHSV2 targets melanoma cells for viral lysis and immune activation after PD-1 treatment failure.

Asymmetric biphasic pulses transfer nucleic acids into mammalian cells while reducing muscle twitching 2- to 5-fold versus monophasic GET.

Intermediate-frequency TTFields increase reversible membrane permeability, helping 5-ALA uptake and glioblastoma tumor delineation.

A synthetic antigen mimics the spike–ACE2 intermediate structure to elicit neutralizing antibodies across SARS-CoV-2 variants.

Bi-phasic microbubble and microdroplet clusters increase drug loading and retention while enabling low-power ultrasound activation.

This case combines IL-12, hTERT/WT-1/PSMA antigens, and PD-1 blockade after biomarker testing to improve glioblastoma survival.

Ultrasound imaging guides microbubble delivery of thrombolytic genes at DVT sites, reducing systemic bleeding exposure and treatment time.

Electromagnetic fields target analgesics through skin while limiting systemic loss.

Vectors carrying microRNA-101 cross the blood-brain barrier to modulate neuronal activity and reduce refractory seizure symptoms.

Cavitation expands round window membrane porosity, enabling drug penetration into the inner ear without invasive procedures.

Functionalized microbubbles carry thrombolytic agents on their lipid shells for targeted ultrasound activation.

Extracted linear FAP epitopes induce specific immune activation to break tumor microenvironment tolerance without lethal CAR-T toxicity.

Ultrasound cavitation drives microparticles deep into tumors, bypassing vasculature constraints to treat larger areas.

Cas9 endonucleases and guide RNAs edit the C9ORF72 gene to delete expanded hexanucleotide repeats, halting ALS progression.

Proline-to-alanine substitutions stabilize HIF-1alpha against degradation, enhancing collateral vessel formation to reduce tissue necrosis.

A dual-phase emulsion uses ultrasound-vaporized droplets to transiently open the blood-brain barrier.

Applying electric pulses induces electroporation to increase cell membrane permeability, enabling lower drug doses while reducing systemic toxicity.

Ultrasound sonophoresis activates the complex to boost anti-tumor effects while reducing systemic side effects.

Preventing vasospasm via calcium blockers maintains blood flow and improves therapeutic efficacy.

Quaternized starch complexes condense RNA for cellular uptake, resolving endosomal release bottlenecks while reducing cytotoxicity.

Electroporation introduces neurotrophic factor genes into cochlear tissues, resolving short drug duration and immunological risks.

Intratumoral expression vectors deliver secretable vaccine proteins and costimulatory molecules to convert cold tumors into hot ones.

Aptamer-modified nucleic acids utilize ultrasonic cavitation for targeted cellular delivery.

Nano-bubble water exposed to low-intensity ultrasound opens the blood-brain barrier for deep brain drug delivery without liposome antigenicity.

Magnetic nanoparticles deliver biomolecules across cell membranes using magnetic fields and ultrasound, avoiding immune responses from viral vectors.

Combines electroporation with T cell activating agents to treat cancer.

Acid-triggered calcium peroxide nanoparticles release oxygen to overcome hypoxia and improve photodynamic therapy efficacy.

Polypeptide particles generate inertial cavitation via ultrasound to enable extravascular drug delivery.

Guiding-agent-conjugated field-electric nanoparticles generate localized electric fields to disrupt targeted pathogens.