Special Delivery TRIZ Cases
- Transcolonic Drug Delivery via Mixed Micelle Permeability
Lipoprotein-bound active agents traverse epithelial layers using fatty acid surfactant carriers, resolving low permeability constraints.
- CRISPR-Cas9 Vector Delivery for Precise Cancer Mutation Modeling
A CRISPR-Cas9 vector delivers multiple guide RNAs to introduce specific genetic mutations in transgenic animal models.
- AAV8 Vector IGF-1 Gene Therapy for Type 1 Diabetes
An AAV8 vector delivers IGF-1 to pancreatic beta cells, protecting against autoimmune destruction while maintaining physiological glucose regulation.
- Nucleic Acid Assemblies for CRISPR Delivery
Nucleic acid assemblies enclose CRISPR components to enable targeted delivery while reducing cytotoxicity and off-target editing.
- Anti-miR-141-3p Oligonucleotides for Ischemic Stroke Neuroprotection
Phosphorothioate anti-miR-141-3p oligonucleotides encapsulated in biocompatible nanoparticles modulate target levels to reduce infarct volume.
- Exosome Loading via Cell Perforation and Resealing
A cell resealing system incorporates arbitrary molecules into exosomes using biological toxins, ATP, and calcium ions.
- C-Met Aptamer Drug Conjugate for Tumor Inhibition
A c-Met targeted aptamer drug conjugate links SL1 to a tubulin inhibitor via covalent bonds.