Special Delivery TRIZ Cases
- ATS-R9 Peptide Gene Delivery to Adipocytes
An ATS-R9 peptide vector binds prohibitin on mature adipocytes, delivering siRNA with high efficiency while avoiding viral immunogenicity.
- Antibody-Biomolecule Conjugates via Cationic Linkers
A cationic macromolecule linker connects an antibody targeting moiety to siRNA for targeted delivery.
- Antigen-Coated Particles for Fc Receptor Drug Delivery
Antigen-coated particles recruit endogenous antibodies to target immune cells via Fc receptors, bypassing complex Fc domain manufacturing.
- Biotinylated siRNA Tumor Targeting via Avidin Binding
Conjugating biotin to siRNA termini enhances intracellular delivery and gene silencing while reducing non-specific immune stimulation.
- Arginine-Grafted Bioreducible Polymers for Gene Delivery
High molecular weight arginine-grafted bioreducible polymers form stable polyplexes, resolving premature gene release and cytotoxicity trade-offs.
- miRNA Oligonucleotide Therapeutics with Active Targeting for Cardio-Metabolic Diseases
Active targeting delivery of miRNA agomirs and antagomirs to adipocytes using fatty acid translocase transporters.
- Allelic Exchange for Compound Heterozygous Mutation Repair
Recombinant gene editing complex mediates allelic exchange between homologous chromosomes to correct disease-associated mutations.
- Bacterial Minicells for Targeted RNA Delivery
Bacterial minicells protect packaged nucleic acids from serum degradation and renal excretion while enabling targeted delivery to specific cell surfaces.
- Autophagic Inhibitors for Endometriosis Lesion Reduction
Autophagic inhibitors suppress cell survival pathways in endometriotic tissue, reducing lesion size while preserving fertility potential.
- CRISPR Nanocomplex Polymer Carrier Delivery
Polymer-conjugated CRISPR nanocomplex enables intracellular delivery of enzyme proteins and sgRNA without external physical stimulation.
- Nanoformulated ART and CRISPR Eradication Strategy
Addresses persistent HIV reservoirs by merging LASER ART suppression with CRISPR-mediated DNA excision, achieving complete viral eradication without rebound.