Steroids Preparation TRIZ Cases
- GABAA Modulator Compounds for CNS Excitability Control
Novel GABAA-modulating compounds regulate chloride ion flow to control brain excitability while addressing limits and side effects of older CNS therapies.
- Estetrol Synthesis via Permanganate Oxidation
Permanganate oxidation replaces osmium to improve yield and purity, avoiding extensive purification steps.
- Drospirenone Synthesis via Ruthenium Catalysis
Ruthenium salt catalyst enables selective oxidation of triol precursors, eliminating toxic chromium reagents and chromatography purification steps.
- Exemestane Synthesis via Chloranil Oxidation in NMP
Chloranil oxidation in N-methylpyrrolidine yields high-purity Exemestane, resolving low conversion and impurity issues.
- Ceragenin Synthesis via Cholic Acid Etherification and Amination
Converting cholic acid into ceragenins via etherification and amination steps to create non-peptide mimics that resist proteolytic degradation.
- Nicotinate Base Triflation of Steroid Derivatives
Methyl nicotinate converts steroid derivatives to vinyl triflates, avoiding impurities from expensive bases.
- Stereoselective Gestonorone Synthesis via Silyl Ether Cyanohydrin
A stereoselective process converts 3-methoxyestra-dien-one to gestonorone using a silyl ether protected cyanohydrine precursor.
- Galeterone Synthesis via Filtration Purification
A simplified Galeterone synthesis route uses acid filtration to purify the product directly.
- Ceragenin Synthesis via Phase Transfer Catalysis
Phase transfer catalysis synthesizes stable ceragenins, avoiding protease deactivation and high costs of peptide therapeutics.
- Trimethylsilyl Iodide Deoxygenation of 17-Hydroxy Corticosteroids
Trimethylsilyl Iodide selectively removes the hydroxyl group at position 17, preserving halogen groups and eliminating multi-step protection requirements.
- Synthesizing 17α-Ethynyl-Androstane Steroids Without Receptor Impurities
A reaction sequence introduces an alkynyl group at position 17 and a hydroxy group at position 7 in androst-5-ene derivatives.