Transferases TRIZ Cases
- Engineered Aminotransaminase for Chiral Amine Synthesis
Engineered aminotransaminase catalyzes chiral amine production via site-directed mutagenesis.
- PTH1 Ligand-Bound Nucleic Acid Complex for Organ-Specific Delivery
A PTH1 ligand-bound nucleic acid complex directs antisense oligonucleotides to target organs via receptor-mediated uptake.
- Metabolically Engineered Microorganisms for Globosides Production
Enzymatic synthesis using metabolically engineered microorganisms overcomes low yields and complex protection steps in chemical globoside production.
- Eubacterium rectale Reverse Transcriptase for Long RNA Sequencing
Engineered Eubacterium rectale reverse transcriptase achieves enhanced processivity to resolve low read length accuracy in complex RNA sequencing applications.
- OTC Polyribonucleotides for Enzyme Replacement Therapy
Polyribonucleotides encoding ornithine transcarbamylase replace liver transplantation by restoring enzyme activity.
- Mutant DNA Polymerases Enhancing Reverse Transcriptase Efficiency
Mutant DNA polymerases with specific amino acid substitutions increase reverse transcriptase efficiency for primer extension methods.
- Enzymatic Cyclization of Homofarnesylic Acid to Sclareolide
Squalene-hopene cyclase replaces harsh chemical oxidation, reducing energy consumption and eliminating polluting waste during sclareolide production.
- Transgene Expression via Transposon ITR Integration
Inverted terminal repeats direct transgene integration into the host genome, eliminating harmful episomal expression bursts.
- Acetyl-CoA Production via ATP-Independent ADA Enzyme
Heterologous acylating acetaldehyde dehydrogenase converts acetaldehyde to acetyl-CoA without ATP expenditure.
- Engineered Immune Cells Promoting Thanotransmission
Engineered immune cells express heterologous polynucleotides to promote thanotransmission, overcoming limited tumor reduction in current immunotherapies.
- Plant EPSPS A138T Mutation Glyphosate Resistance
An A138T plant EPSPS mutant provides glyphosate resistance without microbial transgenes, resolving public acceptance issues in crop engineering.
- Pol6 Polymerase Variants for Nanopore Sequencing Stability
Targeted amino acid mutations in Pol6 polymerase decrease template dissociation, resolving nanopore sequencing instability at high salt concentrations.
- Anti-Tie2 Antibodies Block Ligand Binding
Segmented variable regions optimize binding affinity for therapeutic efficacy.
- Heterologous Octaketide Synthase Production of Carminic Acid
Heterologous expression of octaketide synthase produces carminic acid, eliminating insect protein allergens and supply fluctuations.