Viruses TRIZ Cases
- Humanized Anti-GPC3 Antibodies for CAR-T Specificity
Humanized anti-GPC3 antibodies resolve immunogenicity risks in CAR-T therapy by targeting hepatocellular carcinoma without triggering allergic reactions.
- Vascular Cell Preconditioning for Transduction Efficiency
DEAE-Dextran preconditioning resolves the contradiction between high angiogenic potential and low transduction efficiency in vascular cell therapy.
- Urine Exosome Isolation for HIV Biomarker Detection
Centrifugal separation of urine exosomes enables detection of HIV-associated proteins, resolving the trade-off between diagnostic accuracy and patient comfort.
- Anti-LIV1 CAR T Cells for Cancer Targeting
Engineered T cells express anti-LIV1 chimeric antigen receptors to bind and lyse LIV1-positive cancer cells.
- Endogenous Protein Tagging via Homology-Directed Repair
A targeting endonuclease creates a double-stranded break to enable homology-directed repair for in-frame tag integration.
- Avidin-Streptavidin Surface Expression for Cancer Targeting
Segmented targeting reduces background noise while improving imaging specificity and treatment coverage.
- Integral Membrane Protein Display on Poxvirus Virions
Fusing integral membrane proteins with vaccinia F13L displays them on extracellular enveloped virions, resolving bacterial folding failures.
- E4ORF1-Engineered Endothelial Cells for BBB Barrier Function
Engineered E4ORF1+ endothelial cells generate blood-brain barrier-like tissues with high trans-endothelial electrical resistance.
- iPSC Reprogramming for Regenerative Medicine
Induced pluripotent stem cells generated from adult tissue samples enable versatile regenerative medicine applications.
- Radiation-Responsive Promoter for Localized TNF-α Expression
A genetic construct uses a radiation-responsive promoter to drive localized therapeutic gene expression within targeted tissues.