3D Biopsy Device With Optical Imaging For Tumor Boundary Detection
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Solution Overview
Problem
Current biopsy methods often fail to precisely identify the boundaries of small tumors, leading to incorrect biopsy locations and increased risks of false diagnoses, as standard imaging modalities struggle to accurately guide the biopsy needle.
Innovation Solution
A 3D biopsy system featuring a transparent biopsy tube with a silicone coating, optical fibers for real-time tissue inspection, and a biopsy device with a notch for precise tissue sampling, allowing for correlation with medical imaging and molecular diagnostic data, enabling a tumour heterogeneity map and appropriate drug selection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If standard imaging modalities are used to guide biopsy needle positioning, then the biopsy procedure can be performed, but the precision of identifying tumor boundaries is insufficient leading to incorrect biopsy locations
Solution Approach 1:
The patent employs optical imaging to visualize tumor boundaries with enhanced contrast, allowing precise identification of tumor margins. The optical imaging system provides real-time visualization that enables accurate needle positioning at the correct tumor location, directly addressing the limitation of standard imaging modalities in identifying tumor boundaries.
2Ease of operation
If a traditional biopsy device is used, then tissue sampling can be performed, but the tissue sample may be fragmented making correlation with imaging data difficult
Solution Approach 1:
The biopsy device features a nested structure with an outer sleeve, main shaft, tube shaft, and biopsy tube arranged concentrically. The biopsy tube is movable within the tube shaft, which is movable within the main shaft, which is surrounded by the outer sleeve. This nested configuration allows the biopsy tube to be advanced and retracted while maintaining its position within the larger device structure, enabling intact tissue sampling that preserves spatial information for correlation with imaging data.
3Measurement precision
If a biopsy device without optical imaging capability is used, then the procedure is simpler, but real-time tissue inspection and correlation with molecular diagnostic data cannot be performed
Solution Approach 1:
The biopsy device integrates multiple functions into a single system: mechanical tissue sampling through the biopsy tube, optical imaging for real-time tissue inspection, and correlation capability with molecular diagnostic data. The device can perform both structural assessment via optical imaging and functional assessment via molecular diagnostics, providing comprehensive tumor characterization without requiring separate devices or procedures.
Data Source
AI summary
A biopsy device for taking a 3D biopsy may comprise an outer sleeve, a hollow main shaft, a biopsy tube and a tube shaft. The hollow main shaft may have a distal end portion with a sideward facing notch, and the main shaft may be adapted to be accommodated within the outer sleeve. The biopsy tube may be provided for receiving cut and thus isolated tissue. A proximal end of the biopsy tube may be releasably attachable to a distal end of the tube shaft so that the biopsy tube is movable together with the tube shaft within the hollow main shaft between a proximal position in which the biopsy tube is not located in the notch, and a distal position in which the biopsy tube is located in the notch.