3D Flexible Neural Electrode for Curved Tissue Adhesion

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Solution Overview

Problem

Existing neural electrodes with two-dimensional structures face challenges in achieving full and close adhesion to curved, three-dimensional objects, limiting their effectiveness in neural signal measurement and stimulation.

Innovation Solution

A neural electrode with a three-dimensional structure formed by a flexible substrate, comprising a flexible first polymer layer, a photoresist part forming a three-dimensional structure, a second polymer layer with protrusion parts, a metal thin film layer, and a third polymer layer with measurement holes, enhancing selective adhesion and accessibility.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If a two-dimensional planar electrode structure is used, then the manufacturing process is simple, but the adhesion to curved three-dimensional surfaces is insufficient

Engineering Contradiction:
Improvemanufacturing process simplicityVSAvoidadhesion to curved surfaces
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The patent transitions from a two-dimensional planar electrode structure to a three-dimensional structure by forming protrusions on the electrode surface. This dimensional change enables the electrode to conform to curved and complex surface geometries, significantly improving adhesion and contact with neural tissue while maintaining compatibility with standard thin-film fabrication processes

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Solution Approach 2:

The patent introduces curved protrusions with specific radii of curvature on the electrode surface. These curved structures allow the electrode to better match the curvature of biological surfaces such as the brain cortex, enhancing mechanical coupling and signal quality without requiring complex custom manufacturing for each application

Inventive Principle:
Principle #14Spheroidality (Curvature)

2Reliability

If the substrate is made thinner to improve flexibility and adhesion, then the adhesion to curved surfaces improves, but the structural strength and stability decrease

Engineering Contradiction:
Improveadhesion to curved surfacesVSAvoidstructural strength and stability
Core Design Contradiction:
ReliabilityVSStrength

Solution Approach 1:

The patent employs a composite structure consisting of multiple layers including flexible polymer substrates (such as PDMS or parylene), metallic conductive layers, and dielectric layers. This multi-material composite approach provides both the flexibility needed for conformal attachment to curved surfaces and the structural integrity required for mechanical stability and long-term reliability

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

By adding vertical protrusions to the thin substrate, the patent creates a three-dimensional structure that increases surface area and mechanical interlocking with the tissue while maintaining overall substrate thinness. This allows thin flexible substrates to achieve both compliance with curved surfaces and sufficient structural strength through geometric reinforcement

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

3Reliability

If a three-dimensional structure is formed to improve adhesion, then the adhesion to complex surfaces improves, but the manufacturing complexity increases

Engineering Contradiction:
Improveadhesion to complex surfacesVSAvoidmanufacturing process complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent forms protrusion patterns in the dielectric or substrate layer before depositing the metallic conductive layers. This preliminary structuring allows subsequent thin-film deposition processes to conformally coat the three-dimensional features, achieving complex 3D electrode geometries using standard sequential fabrication steps without requiring complex post-processing or assembly

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent divides the electrode structure into distinct functional layers (substrate, dielectric, conductor, contact pads) that can be fabricated separately using optimized processes for each material system. This segmentation allows each layer to be processed independently with appropriate materials and techniques, then integrated through conformal deposition and patterning, reducing overall manufacturing complexity

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The three-dimensional neural electrode achieves improved adhesion to complex surfaces, allows for various shapes and protrusion heights, simplifies the manufacturing process, and enables closer contact with target cells, reducing the required stimulation current and minimizing tissue damage.

Implementation Method 1

at least one photoresist part formed on one portion of a surface of the first polymer layer and forming a three-dimensional structure

Methodology Applied
Scientific EffectPhotopolymerization: Photopolymerisation

Implementation Method 2

a metal thin film layer formed by patterning a metal thin film on a surface of the second polymer layer and a surface of the protrusion part

Methodology Applied
Scientific EffectVapor deposition: Physical Vapour Deposition

Data Source

PatentUS12324909B2Neural electrode based on three-dimensional structure of flexible substrate, and manufacturing method therefor
Publication Date: 2025.06.10 DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
  • US12324909B2 patent drawing
  • US12324909B2 patent drawing
  • US12324909B2 patent drawing

AI summary

One embodiment of the present invention provides a flexible neural electrode having improved adherence to an object by using a three-dimensional structure. A neural electrode based on the three-dimensional structure of a flexible substrate, according to one embodiment of the present invention, comprises: a first polymer layer, which is formed from a polymer material, is flexible, and functions as a base; at least one photoresist part, which is formed on one portion of the surface of the first polymer layer and forms a three-dimensional structure; a second polymer layer which is formed on the photoresist part and the rest of the surface of the first polymer layer, and which comprises protrusion parts caused by the photoresist part; a metal thin film layer formed by patterning a metal thin film on the surface of the second polymer layer and the surface of the protrusion parts; and a third polymer layer which is formed on the surface of the second polymer layer and the metal thin film layer so as to function as a covering, and which comprises measurement holes formed so that one portion of the metal thin film layer formed at the ends of the protrusion parts is exposed to the outside.