3D Neural Probe Array via Planar Segmentation
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Solution Overview
Problem
Conventional electrode arrays are limited to two-dimensional arrangements, restricting their ability to interface with neural tissue in a three-dimensional manner, which is necessary for precise communication with the complex structure of the nervous system.
Innovation Solution
A method of creating a three-dimensional electrode array by aligning multiple two-dimensional planar silicon microelectrode arrays in an x, y, and z configuration, supported by a pedestal and connected via flexible ribbon cables, allowing for customizable and scalable neural interface.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If conventional two-dimensional electrode arrays are used, then manufacturing and alignment are simpler, but the ability to interface with three-dimensional neural tissue structure is limited
Solution Approach 1:
The three-dimensional electrode array is segmented into multiple two-dimensional planar silicon microelectrode arrays, each containing multiple electrode contacts. These segmented planar arrays are then assembled in a three-dimensional configuration with spacing between them, allowing the system to interface with three-dimensional neural tissue while maintaining the manufacturing simplicity of individual planar arrays.
Solution Approach 2:
The invention transitions from two-dimensional planar electrode arrays to a three-dimensional electrode array configuration by spacing multiple planar arrays apart from each other along a third dimension. This dimensional expansion allows electrode contacts to be positioned at multiple depths within neural tissue, enabling true three-dimensional neural interfacing.
2Measurement precision
If electrode contacts are positioned in a three-dimensional arrangement, then communication pathways with neural circuits are enriched, but positioning precision requirements increase
Solution Approach 1:
The planar silicon microelectrode arrays are pre-fabricated with precise electrode contact positions using established semiconductor manufacturing techniques before assembly. This preliminary fabrication ensures high manufacturing precision for each individual array, and the subsequent assembly process maintains this precision by positioning the pre-fabricated arrays in a three-dimensional configuration with controlled spacing.
Data Source
AI summary
A three-dimensional neural probe electrode array system is described. Planar probes are microfabricated and electrically connected to flexible micro-machined ribbon cables using a rivet bonding technique. The distal end of each cable is connected to a probe with the proximal end of the cable being customized for connection to a printed circuit board. Final assembly consists of combining multiple such assemblies into a single structure. Each of the two-dimensional neural probe arrays is positioned into a micro-machined platform that provides mechanical support and alignment for each array. Lastly, a micro-machined cap is placed on top of each neural electrode probe and cable assembly to protect them from damage during shipping and subsequent use. The cap provides a relatively planar surface for attachment of a computer controlled inserter for precise insertion into the tissue.