3D Vessel Reconstruction With Multimodal OCT Co-Registration
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Solution Overview
Problem
Current imaging technologies face challenges in accurately reconstructing 3D structures of vessels during procedures like PCI due to information overload and technical difficulties, leading to inconsistent and time-consuming CFD-based reconstructions that hinder real-time decision-making.
Innovation Solution
A system and method utilizing multiple imaging modalities, including OCT and NIRAF, to enhance 3D structure reconstruction by integrating angiography and intravascular imaging, enabling accurate in-plane orientation and plaque information, and employing CFD for real-time physiological assessment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple imaging modalities (OCT, angiography, NIRAF) are integrated for 3D reconstruction, then measurement precision and reliability improve, but device complexity and information processing burden increase
Solution Approach 1:
The patent combines multiple imaging modalities (OCT, angiography, NIRAF) into a single integrated system that captures data from different imaging techniques simultaneously or sequentially. The co-registration module merges these different data sources into a unified 3D reconstruction, allowing the system to leverage the strengths of each modality (OCT for high-resolution cross-sectional images, angiography for vascular tree structure, NIRAF for molecular information) while maintaining a coordinated workflow that reduces the burden of managing separate systems.
Solution Approach 2:
The imaging system is designed with multi-functionality to perform multiple imaging tasks through a single platform. The system can switch between or combine OCT imaging, angiography, and NIRAF imaging modes, making it a universal tool that replaces or supplements multiple separate imaging systems. This multi-functional approach allows the system to adapt to different diagnostic needs while maintaining consistent data processing and 3D reconstruction capabilities.
2Measurement precision
If CFD-based technology is used for physiological assessment, then measurement precision improves, but loss of time increases due to reconstruction processing requirements
Solution Approach 1:
The system performs 3D reconstruction and co-registration of imaging data as a preliminary step before CFD-based physiological assessment. By preparing the 3D structural model and integrating multiple imaging modalities in advance, the system ensures that when CFD analysis is initiated, the necessary geometric and boundary condition data are already processed and ready, reducing the overall time required for physiological assessment while maintaining high precision through accurate 3D models.
3Measurement precision
If invasive measurement technology is used for FFR and iFR assessment, then measurement precision may improve, but ease of operation deteriorates due to vasodilator injection requirements and technical difficulties
Solution Approach 1:
The system replaces the mechanical and pharmacological intervention of vasodilator injection with a computational approach. Instead of requiring physical injection and manual measurement procedures, the system uses CFD-based computational fluid dynamics to calculate FFR and iFR values from the 3D reconstructed vascular geometry. This substitution eliminates the need for vasodilator administration and reduces technical difficulties associated with invasive measurement techniques while maintaining or improving measurement precision through accurate 3D modeling and computational analysis.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Facilitates accurate and real-time 3D structure reconstruction, improving PCI planning and procedural success by providing precise FFR calculations and reducing technical inconsistencies.
Implementation Method 1
OCT is a technique for obtaining high-resolution cross-sectional images of tissues or materials, and enables real time visualization. The aim of the OCT techniques is to measure the time delay of light by using an interference optical system or interferometry
Implementation Method 2
A light from a light source delivers and splits into a reference arm and a sample (or measurement) arm with a splitter (e.g., a beamsplitter)
Data Source
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AI summary
One or more devices, systems, methods and storage mediums for optical imaging medical devices, such as, but not limited to, Optical Coherence Tomography (OCT), single mode OCT, and/or multi-modal OCT apparatuses and systems, and methods and storage mediums for use with same, for viewing, controlling, updating, and emphasizing one or more imaging modalities and/or for constructing or reconstructing 2D and/or 3D structure(s) are provided herein. One or more embodiments provide at least one intuitive Graphical User Interface (GUI), method, device, apparatus, system, or storage medium to comprehend information, including, but not limited to, molecular structure of a vessel, and to provide an ability to manipulate the vessel information and/or to construct or reconstruct 2D and/or 3D structure(s) of the vessel to improve or maximize accuracy in one or more images. In addition to controlling one or more imaging modalities, the GUI may operate for one or more applications, including, but not limited to, expansion/underexpansion (e.g., for a stent) and/or apposition/malapposition (e.g., for a stent), co-registration, and imaging.