4-Hydroxyacetophenone Cosmetic Composition for Low-Temperature Solubilization

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Solution Overview

Problem

4-hydroxyacetophenone has limited solubility in water and requires high temperatures for solubilization, which is energy-consuming and can damage other cosmetic ingredients, necessitating a stable water phase without such heating.

Innovation Solution

A cosmetic composition is formulated with solubilized 4-hydroxyacetophenone and niacinamide, with a weight ratio greater than 3.0, to create a stable water phase that maintains solubility at low temperatures.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If 4-hydroxyacetophenone is solubilized in water by heating to temperatures at or greater than 60°C, then solubility is improved, but energy consumption increases and other cosmetic ingredients are adversely affected

Engineering Contradiction:
Improvesolubility of 4-hydroxyacetophenoneVSAvoidenergy consumption
Core Design Contradiction:
Stability of the object's compositionVSUse of energy by stationary object

Solution Approach 1:

The patent uses surfactants as intermediary substances to facilitate the solubilization of 4-hydroxyacetophenone in water without requiring high temperatures. The surfactants act as mediators between the hydrophobic 4-hydroxyacetophenone and hydrophilic water, enabling solubility through micelle formation at ambient temperatures, thus resolving the contradiction between achieving solubility and avoiding energy consumption.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the chemical parameters of the aqueous system by introducing surfactants and co-solvents, which alter the solubility characteristics of water. This parameter change enables 4-hydroxyacetophenone to dissolve at lower temperatures, thereby reducing energy consumption while maintaining adequate solubility for cosmetic applications.

Inventive Principle:
Principle #35Parameter changes

2Stability of the object's composition

If 4-hydroxyacetophenone is solubilized by heating to temperatures at or greater than 60°C, then solubility is improved, but other cosmetic ingredients are adversely affected

Engineering Contradiction:
Improvesolubility of 4-hydroxyacetophenoneVSAvoiddamage to cosmetic ingredients
Core Design Contradiction:
Stability of the object's compositionVSObject-affected harmful factors

Solution Approach 1:

Surfactants serve as intermediary agents that enable 4-hydroxyacetophenone to solubilize in water without the need for high-temperature heating. By forming micellar structures, the surfactants protect temperature-sensitive cosmetic ingredients from thermal degradation while still achieving the desired solubility enhancement for 4-hydroxyacetophenone.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces the thermal mechanism (heating) with a chemical mechanism (surfactant-mediated solubilization). Instead of using heat energy to force dissolution, the system uses surfactant molecules to chemically facilitate solubility through hydrophobic-hydrophilic interactions, thereby eliminating the harmful thermal effects on other cosmetic ingredients.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Reliability

If 4-hydroxyacetophenone is used as a preserving agent, then microbial protection is improved, but solubility in water is limited

Engineering Contradiction:
Improvemicrobial protectionVSAvoidsolubility in water
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent introduces surfactants as intermediaries that bridge the hydrophobic 4-hydroxyacetophenone and hydrophilic water phases. This enables the preserving agent to be effectively distributed throughout the aqueous cosmetic formulation, maintaining its microbial protective function while achieving the necessary solubility for homogeneous product formulation.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition achieves stable solubilization of 4-hydroxyacetophenone without high-temperature processing, maintaining composition integrity and enhancing makeup removal efficacy with sustainable, biodegradable substrates.

Implementation Method 1

4-hydroxyacetophenone with niacinamide is formed by the steps consisting essentially of providing an aqueous composition and combining 4-hydroxyacetophenone and niacinamide

Methodology Applied
Scientific EffectSolubilization: Solvation

Data Source

PatentUS12377031B2Cosmetic compositions comprising 4-hydroxyacetophenone
Publication Date: 2025.08.05 LOREAL SA
  • US12377031B2 patent drawing
  • US12377031B2 patent drawing
  • US12377031B2 patent drawing

AI summary

A cosmetic composition including a water phase, the water phase comprising solubilized 4-hydroxyacetophenone with niacinamide, wherein the weight ratio of niacinamide to 4-hydroxyacetophenone in the water phase is greater than 3.0.